Structural basis for action by diverse antidepressants on biogenic amine transporters (Q27680298)

6

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author name string

Hui Wang

1

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April Goehring

2

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Kevin H Wang

3

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Aravind Penmatsa

4

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Ryan Ressler

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue

5

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language of work or name

English

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publication date

7 November 2013

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published in

Nature

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volume

503

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issue

7474

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page(s)

141-5

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cites work

1 reference

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Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures

20 March 2017

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Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

20 March 2017

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

20 March 2017

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20 March 2017

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Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

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7 April 2017

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29 September 2017

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Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters

29 September 2017

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Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue

29 September 2017

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The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter

29 September 2017

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The two enantiomers of citalopram bind to the human serotonin transporter in reversed orientations

29 September 2017

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The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.

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Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.

29 September 2017

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Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

29 September 2017

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Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

29 September 2017

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Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants

29 September 2017

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Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

29 September 2017

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Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes

2 June 2018

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2 June 2018

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High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol

2 June 2018

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Homology modeling of the serotonin transporter: insights into the primary escitalopram-binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12648

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12648

X-ray structure of dopamine transporter elucidates antidepressant mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12648

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE12648

1 reference

Dimensions Publication ID

1241739

1023231701

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Fatcat ID

release_2ph7w2gx7fdo5oniaccelhx3ma

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2ph7w2gx7fdo5oniaccelhx3ma

mapped directly with Wikidata item

24 November 2022

based on heuristic

1241739

1 reference

1 reference

1 reference