Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex (Q27679932)

Irina Kufareva

6

0 references

Raymond C. Stevens

Raymond C Stevens

17

0 references

Jiang Hualiang

14

Hualiang Jiang

0 references

Gye Won Han

5

Gye Won Han

0 references

Gustavo Fenalti

9

Gustavo Fenalti

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author name string

Qiuxiang Tan

1

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Ya Zhu

2

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Jian Li

3

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Zhuxi Chen

4

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Tingting Li

7

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Limin Ma

8

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Jing Li

10

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Wenru Zhang

11

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Xin Xie

12

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Huaiyu Yang

13

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Hong Liu

16

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Qiang Zhao

18

0 references

Beili Wu

Crystal structure of the β2 adrenergic receptor-Gs protein complex

19

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language of work or name

English

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publication date

20 September 2013

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published in

Science

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volume

341

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page(s)

1387-90

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issue

6152

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cites work

1 reference

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Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

20 March 2017

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Crystal structure of rhodopsin: A G protein-coupled receptor

20 March 2017

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Features and development of Coot

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Chemokines and disease

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CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist

20 March 2017

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Assessing chemokine co-receptor usage in HIV

20 March 2017

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Crystallizing membrane proteins using lipidic mesophases

20 March 2017

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Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

7 April 2017

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Chemokines and leukocyte traffic

7 April 2017

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Characterization of a dual-tropic human immunodeficiency virus (HIV-1) strain derived from the prototypical X4 isolate HXBc2.

7 April 2017

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Structure-function of the G protein-coupled receptor superfamily

29 September 2017

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Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors

29 September 2017

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Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5).

29 September 2017

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Pharmacological modulation of chemokine receptor function.

29 September 2017

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New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection

29 September 2017

1 reference

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The relative activity of "function sparing" HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property?

29 September 2017

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Structural basis for coreceptor selectivity by the HIV type 1 V3 loop

29 September 2017

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Discovery and development of small-molecule chemokine coreceptor CCR5 antagonists

29 September 2017

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Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity

29 September 2017

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Functional impact of HIV coreceptor-binding site mutations

29 September 2017

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The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor

29 September 2017

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Identification of conserved and variable structures in the human immunodeficiency virus gp120 glycoprotein of importance for CXCR4 binding

29 September 2017

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Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop

29 September 2017

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Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins

29 September 2017

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Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity

29 September 2017

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Recognition of RANTES by extracellular parts of the CCR5 receptor.

2 June 2018

1 reference

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The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle

21 January 2018

1 reference

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Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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FDA notifications. Maraviroc approved as a CCR5 co-receptor antagonist

21 January 2018

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27 November 2018

Identifiers

DOI

10.1126/SCIENCE.1241475

1 reference

release_eech3w5d75ftndli4bptk7iyta

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/eech3w5d75ftndli4bptk7iyta

mapped directly with Wikidata item

24 November 2022

based on heuristic

499200

1 reference

1 reference

1 reference