Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist (Q27666030)

10

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Jonathan Javitch

Jonathan A Javitch

9

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Amy Hauck Newman

8

Amy Hauck Newman

0 references

Raymond C Stevens

11

Raymond C Stevens

0 references

Michael A Hanson

6

Michael A Hanson

0 references

Gye Won Han

5

Gye Won Han

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Ellen Y T Chien

1

Ellen Y T Chien

0 references

Wei Liu

2

Wei Liu

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author name string

Qiang Zhao

3

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Lei Shi

N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists

7

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language of work or name

English

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publication date

19 November 2010

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published in

Science

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volume

330

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page(s)

1091-5

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issue

6007

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cites work

1 reference

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Dopamine D2 receptors form higher order oligomers at physiological expression levels

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A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

20 March 2017

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

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Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats

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Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

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The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats

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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

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Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

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Allele-specific activation of genetically engineered receptors

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Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor

20 March 2017

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The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors

20 March 2017

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Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders

22 April 2017

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Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure

29 September 2017

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The structural evolution of dopamine D3 receptor ligands: structure-activity relationships and selected neuropharmacological aspects

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Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors

29 September 2017

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Phenotypic analysis of dopamine receptor knockout mice; recent insights into the functional specificity of dopamine receptor subtypes

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Identification and characterization of novel properties of the human D3 dopamine receptor

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The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop

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The first transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle

29 September 2017

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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

29 September 2017

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The probable arrangement of the helices in G protein-coupled receptors.

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The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats.

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21097933

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1197410

1 reference

258131

ADS bibcode

2010Sci...330.1091C

0 references

258131

1 reference

1 reference

1 reference