Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic (Q27679151)

12

0 references

Huixian Wu

Huixian Wu

5

0 references

Xi-Ping Huang

Xi-Ping Huang

7

0 references

Claudio Trapella

Claudio Trapella

8

0 references

Remo Guerrini

Remo Guerrini

9

0 references

Bryan L. Roth

11

Bryan L Roth

0 references

Raymond C Stevens

13

Raymond C Stevens

0 references

Eyal Vardy

6

Eyal Vardy

0 references

Girolamo Calò

10

Girolamo Calo

0 references

Wei Liu

2

Wei Liu

0 references

author name string

Aaron A Thompson

1

0 references

Eugene Chun

Structure of the human κ-opioid receptor in complex with JDTic

3

0 references

language of work or name

English

0 references

publication date

16 May 2012

0 references

published in

Nature

0 references

volume

485

0 references

page(s)

395-9

0 references

issue

7398

0 references

cites work

1 reference

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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

20 March 2017

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Diversity and modularity of G protein-coupled receptor structures

20 March 2017

1 reference

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Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

20 March 2017

1 reference

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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

20 March 2017

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 March 2017

1 reference

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Structural Determinants of G-protein Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

20 March 2017

1 reference

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Redesign of a four-helix bundle protein by phage display coupled with proteolysis and structural characterization by NMR and X-ray crystallography

20 March 2017

1 reference

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Electrostatics of nanosystems: application to microtubules and the ribosome

20 March 2017

1 reference

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ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization

20 March 2017

1 reference

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Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

1 reference

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Phasercrystallographic software

20 March 2017

1 reference

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Functional inactivation of the nociceptin receptor by alanine substitution of glutamine 286 at the C terminus of transmembrane segment VI: evidence from a site-directed mutagenesis study of the ORL1 receptor transmembrane-binding domain

20 March 2017

1 reference

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The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

20 March 2017

1 reference

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Crystallizing membrane proteins using lipidic mesophases

7 April 2017

1 reference

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Gene splicing and mutagenesis by PCR-driven overlap extension

7 April 2017

1 reference

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Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

7 April 2017

1 reference

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Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

The nociceptin pharmacophore site for opioid receptor binding derived from the NMR structure and bioactivity relationships.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

Identification of a hexapeptide binding region in the nociceptin (ORL1) receptor by photo-affinity labelling with Ac-Arg-Bpa-Tyr-Arg-Trp-Arg-NH2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

Specific receptor for the opioid peptide dynorphin: structure--activity relationships

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

Flexible protein-ligand docking by global energy optimization in internal coordinates.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

Moving from the orphanin FQ receptor to an opioid receptor using four point mutations

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510).

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

Structural modelling and mutation analysis of a nociceptin receptor and its ligand complexes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

Creating a functional opioid alkaloid binding site in the orphanin FQ receptor through site-directed mutagenesis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356928

Further Studies on Nociceptin-Related Peptides: Discovery of a New Chemical Template with Antagonist Activity on the Nociceptin Receptor

27 November 2018

1 reference

12 December 2020

Dopamine–nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: Involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activity

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Comparison of the structure-activity relationships of nociceptin and dynorphin A using chimeric peptides

1 reference

12 December 2020

Molecular modelling of the ORL1 receptor and its complex with nociceptin

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE11085

1 reference

Dimensions Publication ID

3280653

1026270837

0 references

3280653

1 reference

1 reference

1 reference