Structure of the mitotic checkpoint complex (Q27678130)

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Kiran Kulkarni

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Eric H Kong

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David Barford

The spindle-assembly checkpoint in space and time

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language of work or name

English

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publication date

21 March 2012

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published in

Nature

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volume

484

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page(s)

208-13

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issue

7393

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Feedback control of mitosis in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Budding yeast Cdc20: a target of the spindle checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Protein metamorphosis: the two-state behavior of Mad2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Structure, function and mechanism of the anaphase promoting complex (APC/C).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Cyclin is degraded by the ubiquitin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Identification of a MAD2-binding protein, CMT2, and its role in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

p31comet blocks Mad2 activation through structural mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

The APC subunit Doc1 promotes recognition of the substrate destruction box.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Structural basis for the subunit assembly of the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Baculovirus expression system for heterologous multiprotein complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Scaling and assessment of data quality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Coot: model-building tools for molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

PHENIX: building new software for automated crystallographic structure determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10896

Purification and Assay of the Budding Yeast Anaphase‐Promoting Complex

21 January 2018

1 reference

12 December 2020

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

1 reference

12 December 2020

Implementation of molecular replacement in AMoRe

1 reference

12 December 2020

A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment

1 reference

12 December 2020

Mutual regulation between the spindle checkpoint and APC/C.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE10896

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

3693448

1004970449

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3693448

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference