Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants (Q27679084)

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1 February 2020

title

Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants (English)

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8

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Takashi Kumasaka

9

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Masaki Yamamoto

10

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author name string

Shin Muraoka

1

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Fumi Shima

2

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Mitsugu Araki

3

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Tomoko Inoue

4

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Akiko Yoshimoto

5

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Yuichi Ijiri

6

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Nobuaki Seki

7

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Tohru Kataoka

11

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language of work or name

English

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publication date

11 May 2012

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volume

586

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issue

12

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page(s)

1715-1718

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Ras oncogenes: split personalities

1 February 2020

cites work

1 reference

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The guanine nucleotide-binding switch in three dimensions

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Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

21 January 2018

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

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Structure of the G60A mutant of Ras: implications for the dominant negative effect

21 January 2018

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Allosteric modulation of Ras positions Q61 for a direct role in catalysis

21 January 2018

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Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.

21 January 2018

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Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases

21 January 2018

1 reference

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Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers

21 January 2018

1 reference

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Dynamic properties of the Ras switch I region and its importance for binding to effectors

21 January 2018

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

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Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy

21 January 2018

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Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

21 January 2018

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The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins

21 January 2018

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Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis

21 January 2018

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21 January 2018

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

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1 February 2020

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Consolidated OpenCitations Corpus – April 2017

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