Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential (Q27670499)

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English	Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential	scientific article

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scholarly article

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Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential (English)

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Plasmodium falciparum

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Iñigo Angulo-Barturen

13

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Susan A. Charman

object named as

Susan A Charman

24

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William N. Charman

object named as

William N Charman

18

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22

object named as

Jeremy N Burrows

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Margaret A. Phillips

25

object named as

Margaret A Phillips

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Pradipsinh K. Rathod

23

object named as

Pradipsinh K Rathod

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Elizabeth J. Goldsmith

17

object named as

Elizabeth J Goldsmith

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19

object named as

Ian Bathurst

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Farah El Mazouni

8

object named as

Farah El Mazouni

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Maria Belen Jimenez-Diaz

15

object named as

María Belén Jiménez-Díaz

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David M Shackleford

12

object named as

David M Shackleford

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Francisco Javier Gamo

16

object named as

Francisco-Javier Gamo

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5

object named as

Karen L White

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Sreekanth Kokkonda

9

object named as

Sreekanth Kokkonda

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Kasiram Katneni

10

object named as

Kasiram Katneni

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author name string

Jose M Coteron

1

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María Marco

2

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Jorge Esquivias

3

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Xiaoyi Deng

4

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Maria Koltun

7

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Ravi Bhamidipati

11

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Santiago B Ferrer

14

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David Floyd

20

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David Matthews

21

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John White

6

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language of work or name

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publication date

11 August 2011

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Journal of Medicinal Chemistry

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54

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15

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5540-61

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Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

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Thousands of chemical starting points for antimalarial lead identification

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Artemisinin resistance: current status and scenarios for containment

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Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

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Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes

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Malaria: progress, perils, and prospects for eradication

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The limits and intensity of Plasmodium falciparum transmission: implications for malaria control and elimination worldwide

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Antimalarial drug resistance

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Solving structures of protein complexes by molecular replacement with Phaser

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Coot: model-building tools for molecular graphics

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Refinement of macromolecular structures by the maximum-likelihood method

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DaliLite workbench for protein structure comparison

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A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes

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Chemical genetics of Plasmodium falciparum

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Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

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7 April 2017

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

1 reference

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29 September 2017

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy

1 reference

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Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

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Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

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12 December 2020

based on heuristic

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Physiological parameters in laboratory animals and humans

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https://pubmed.ncbi.nlm.nih.gov/21696174

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM200592F

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Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

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