Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum (Q33979229)

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English	Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum	scientific article

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum (English)

1 reference

Europe PubMed Central

30 July 2017

Plasmodium falciparum

0 references

Pradipsinh K. Rathod

4

object named as

P K Rathod

1 reference

Europe PubMed Central

30 July 2017

author name string

L Jiang

1

1 reference

Europe PubMed Central

30 July 2017

P C Lee

2

1 reference

Europe PubMed Central

30 July 2017

J White

3

1 reference

Europe PubMed Central

30 July 2017

language of work or name

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publication date

1 April 2000

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Europe PubMed Central

30 July 2017

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

30 July 2017

44

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Europe PubMed Central

30 July 2017

4

1 reference

Europe PubMed Central

30 July 2017

1047-1050

1 reference

Europe PubMed Central

30 July 2017

Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

A mechanism for the synergistic antimalarial action of atovaquone and proguanil

1 reference

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5 July 2018

Variations in frequencies of drug resistance in Plasmodium falciparum

1 reference

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5 July 2018

Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Selection and characterization of 5-fluoroorotate-resistant Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

The catalytic mechanism and structure of thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Fluorinated pyrimidines and their nucleosides

1 reference

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5 July 2018

Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Purification of the bifunctional thymidylate synthase-dihydrofolate reductase complex from the human malaria parasite Plasmodium falciparum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

In vitro susceptibilities of Plasmodium falciparum to compounds which inhibit nucleotide metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Plasmodium yoelii: oral delivery of 5-fluoroorotate to treat malaria in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Metabolism and mechanism of action of 5-fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Antimalarial drug resistance: the pace quickens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Human malaria parasites in continuous culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

5 July 2018

Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

29 October 2018

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

29 October 2018

Altered Dihydrofolate Reductase associated with a Pyrimethamine-resistant Plasmodium berghei berghei produced in a Single Step

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89811

29 October 2018

An Isotopic Assay for Thymidylate Synthetase*

1 reference

https://pubmed.ncbi.nlm.nih.gov/10722510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydrofolate Reductase from Pyrimethamine-resistant Plasmodium berghei

1 reference

https://pubmed.ncbi.nlm.nih.gov/10722510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of growth-limiting events caused by 5-fluorouracil in mouse cells and in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10722510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA fragmentation and cytotoxicity from increased cellular deoxyuridylate

1 reference

https://pubmed.ncbi.nlm.nih.gov/10722510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/10722510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10722510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10722510

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.44.4.1047-1050.2000

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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