A structural view of nuclear hormone receptor: endocrine disruptor interactions (Q27658908)

Cellular and Molecular Life Sciences

Europe PubMed Central

title

A structural view of nuclear hormone receptor: endocrine disruptor interactions (English)

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Albane le Maire

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William Bourguet

series ordinal

2

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Patrick Balaguer

series ordinal

3

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language of work or name

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April 2010

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published in

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volume

67

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issue

8

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page(s)

1219-37

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exact match

https://scigraph.springernature.com/pub.10.1007/s00018-009-0249-2

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ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner

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Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta

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Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates

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Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

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Estrogens and antiestrogens activate hPXR.

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Three-dimensional quantitative structure--activity relationships for androgen receptor ligands

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Environmental endocrine disrupters

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Exploring interactions of endocrine-disrupting compounds with different conformations of the human estrogen receptor alpha ligand binding domain: a molecular docking study.

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SAR and QSAR modeling of endocrine disruptors

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Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition

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In silico-aided prediction of biological properties of chemicals: oestrogen receptor-mediated effects

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Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

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Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway

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Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta

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Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

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Study of 202 Natural, Synthetic, and Environmental Chemicals for Binding to the Androgen Receptor

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Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

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Activation of mammalian retinoid X receptors by the insect growth regulator methoprene

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Bioanalytical characterisation of multiple endocrine- and dioxin-like activities in sediments from reference and impacted small rivers.

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Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.

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Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor

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Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling

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Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression

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The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges

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Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta

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The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators

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Transcriptional control of energy homeostasis by the estrogen-related receptors

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Co-regulator recruitment and the mechanism of retinoic acid receptor synergy

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

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Structural plasticity in the oestrogen receptor ligand-binding domain

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To ERR in the estrogen pathway

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A two-hybrid yeast assay to quantify the effects of xenobiotics on retinoid X receptor-mediated gene expression

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Understanding the selectivity of genistein for human estrogen receptor-beta using X-ray crystallography and computational methods

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Non-steroidal subtype selective estrogens

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Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid

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Coregulator function: a key to understanding tissue specificity of selective receptor modulators

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The current status of the DES-exposed population

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CAR and PXR: xenosensors of endocrine disrupters?

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Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor

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Structural basis of human pregnane X receptor activation by the hops constituent colupulone

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2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

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Use of the nuclear receptor PXR to predict drug interactions

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The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity

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Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation

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12 December 2020

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma

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12 December 2020

An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels

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12 December 2020

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

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Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain

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NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists

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In silico tools to aid risk assessment of endocrine disrupting chemicals

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Development of clear cell adenocarcinoma in DES-exposed offspring under observation

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New modes of action for endocrine-disrupting chemicals

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Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies

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Estrogen receptor null mice: what have we learned and where will they lead us?

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12 December 2020