Use of the nuclear receptor PXR to predict drug interactions (Q34088796)

30 July 2017

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title

Use of the nuclear receptor PXR to predict drug interactions (English)

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30 July 2017

Moore JT

1

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30 July 2017

Kliewer SA

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

1 November 2000

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30 July 2017

10

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inferred from page(s)

published in

Toxicology

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30 July 2017

153

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30 July 2017

1-10

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30 July 2017

1-3

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Steroid hormone receptors: many actors in search of a plot

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes

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Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

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Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids

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Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors.

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The influence of pregnenolone-16 -carbonitrile on hepatic mixed-function oxygenases

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Use of human hepatocytes to study P450 gene induction

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

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Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

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Identifiers

DOI

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release_qtyldjzjwfcbzhgae7klwbz7qy

30 July 2017

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Fatcat

https://api.fatcat.wiki/v0/release/qtyldjzjwfcbzhgae7klwbz7qy

24 November 2022

mapped directly with Wikidata item

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