Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor (Q27650906)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18566589%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor (English)

1 reference

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9 January 2020

1 reference

ChEBI release 2020-05-28

1 reference

8

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9 January 2020

author name string

Jinhua Wu

1

1 reference

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9 January 2020

Wanqing Li

2

1 reference

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9 January 2020

Barbara P Craddock

3

1 reference

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9 January 2020

Kenneth W Foreman

4

1 reference

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9 January 2020

Mark J Mulvihill

5

1 reference

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9 January 2020

Qun-sheng Ji

6

1 reference

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9 January 2020

W Todd Miller

7

1 reference

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9 January 2020

language of work or name

English

0 references

publication date

19 June 2008

1 reference

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9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18566589%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

volume

27

1 reference

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9 January 2020

page(s)

1985-1994

1 reference

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9 January 2020

issue

14

1 reference

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Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

9 January 2020

cites work

1 reference

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Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region

20 March 2017

1 reference

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Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)

20 March 2017

1 reference

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Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

20 March 2017

1 reference

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Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor

20 March 2017

1 reference

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Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 Å resolution

20 March 2017

1 reference

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Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

20 March 2017

1 reference

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Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

20 March 2017

1 reference

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Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

20 March 2017

1 reference

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Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism

20 March 2017

1 reference

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

20 March 2017

1 reference

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

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The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants

20 March 2017

1 reference

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Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology

20 March 2017

1 reference

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Molecular and cellular aspects of the insulin-like growth factor I receptor

20 March 2017

1 reference

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Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II

20 March 2017

1 reference

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The determination of enzyme inhibitor constants

20 March 2017

1 reference

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

7 April 2017

1 reference

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Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

7 April 2017

1 reference

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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

7 April 2017

1 reference

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A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo

7 April 2017

1 reference

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IGF1R signalling and its inhibition

29 September 2017

1 reference

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Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity

29 September 2017

1 reference

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The insulin-like growth factor system and cancer

29 September 2017

1 reference

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IGF-I receptor signalling in transformation and differentiation

29 September 2017

1 reference

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Structure and function of the type 1 insulin-like growth factor receptor.

29 September 2017

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The IGF-I receptor in cancer research

29 September 2017

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Differential role of insulin receptor substrate (IRS)-1 and IRS-2 in L6 skeletal muscle cells expressing the Arg1152 --> Gln insulin receptor

29 September 2017

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YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase

29 September 2017

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In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

29 September 2017

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Multiple activation loop conformations and their regulatory properties in the insulin receptor's kinase domain

2 June 2018

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The IGF-I receptor in cell growth, transformation and apoptosis.

2 June 2018

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Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites de-regulates kinase activity and impairs insulin action

2 June 2018

1 reference

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Expression, characterization, and crystallization of the catalytic core of the human insulin receptor protein-tyrosine kinase domain

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2486273

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2486273

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

2 June 2018

1 reference

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Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

27 November 2018

1 reference

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Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice

27 November 2018

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12 December 2020

NIDDM Associated With Mutation in Tyrosine Kinase Domain of Insulin Receptor Gene

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process

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12 December 2020

MOLREP: an Automated Program for Molecular Replacement

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.116

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/EMBOJ.2008.116

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18566589%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18566589%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

2 references