Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation (Q27650237)

1

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Gopalakrishnan Parthasarathy

2

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Alan D Adams

3

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Soumya Sahoo

4

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Ayesha Sitlani

5

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Carl Sparrow

6

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Jisong Cui

7

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Joseph W Becker

Proceedings of the National Academy of Sciences of the United States of America

8

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language of work or name

English

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publication date

8 April 2008

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published in

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volume

105

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page(s)

5337-42

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issue

14

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cites work

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Identification of a nuclear receptor for bile acids

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LXRS and FXR: the yin and yang of cholesterol and fat metabolism

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Farnesoid X receptor is essential for normal glucose homeostasis

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The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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FXR, a multipurpose nuclear receptor

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

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Automatic Solution of Heavy-Atom Substructures

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