Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction (Q27621560)

2

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X Duan

3

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T E Lloyd

4

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M N Wu

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H Bellen

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F A Quiocho

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

7

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language of work or name

English

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publication date

18 February 2000

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published in

Cell

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volume

100

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issue

4

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page(s)

447-56

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cites work

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Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth

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Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains

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The Rab5 effector EEA1 is a core component of endosome docking

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FYVE fingers bind PtdIns(3)P

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The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

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Three-dimensional structure of the armadillo repeat region of beta-catenin

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The Pleckstrin Homology Domains of Dynamin Isoforms Require Oligomerization for High Affinity Phosphoinositide Binding

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Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain

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Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis

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Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes

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Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain

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VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking

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EAST, an epidermal growth factor receptor- and Eps15-associated protein with Src homology 3 and tyrosine-based activation motif domains

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Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p

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Processing of X-ray diffraction data collected in oscillation mode

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A functional PtdIns(3)P-binding motif.

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VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae

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Structure of the lamprey yolk lipid-protein complex lipovitellin-phosvitin at 2.8 Å resolution

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Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger

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Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue

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