SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro (Q27490844)

2

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Zhuhui Huang

3

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Michael G Murray

4

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Stephen Wring

5

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Craig Smitley

6

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Richard Harris

7

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Frank Erdmann

8

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Gunter Fischer

9

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Yves Ribeill

Antimicrobial Agents and Chemotherapy

10

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language of work or name

English

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publication date

February 2010

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published in

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volume

54

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page(s)

660-72

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issue

2

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cites work

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The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

20 March 2017

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Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro

20 March 2017

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NIM811, a Cyclophilin Inhibitor, Exhibits Potent In Vitro Activity against Hepatitis C Virus Alone or in Combination with Alpha Interferon

20 March 2017

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Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions

20 March 2017

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Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose

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7 April 2017

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7 April 2017

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7 April 2017

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Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

7 April 2017

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Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition

7 April 2017

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The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro

29 September 2017

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29 September 2017

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Viral hepatitis: new data on hepatitis C infection

29 September 2017

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Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes

29 September 2017

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29 September 2017

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29 September 2017

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Effect of cyclosporine on proliferation of non-A, non-B hepatitis virus

29 September 2017

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The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.

2 June 2018

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Optimizing classification of drug-drug interaction potential for CYP450 isoenzyme inhibition assays in early drug discovery.

27 November 2018

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Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids.

27 November 2018

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In vitro metabolism of cyclosporine A by human kidney CYP3A5.

27 November 2018

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Antiviral action of ribavirin in chronic hepatitis C.

27 November 2018

1 reference

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Substitution in position 3 of cyclosporin A abolishes the cyclophilin-mediated gain-of-function mechanism but not immunosuppression.

27 November 2018

1 reference

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27 November 2018

1 reference

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Characterization of cyclosporine A uptake in human erythrocytes

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19933795

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cyclophilin A differentially activates monocytes and endothelial cells: role of purity, activity, and endotoxin contamination in commercial preparations

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19933795