Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes (Q27305777)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25789755%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes (English)

1 reference

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3 March 2020

1 reference

5

1 reference

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3 March 2020

author name string

Brenda Huang

1

1 reference

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3 March 2020

WenJie Wei

2

1 reference

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3 March 2020

Guohao Wang

3

1 reference

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3 March 2020

Marta A Gaertig

4

1 reference

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3 March 2020

Wei Wang

6

1 reference

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3 March 2020

Xiao-Jiang Li

7

1 reference

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3 March 2020

Shihua Li

8

1 reference

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3 March 2020

language of work or name

English

0 references

publication date

1 March 2015

1 reference

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3 March 2020

1 reference

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3 March 2020

volume

85

1 reference

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3 March 2020

issue

6

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3 March 2020

page(s)

1212-1226

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describes a project that uses

3 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4366619/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes

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The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease

21 March 2017

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Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination

21 March 2017

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Interaction of Huntington disease protein with transcriptional activator Sp1

21 March 2017

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The hunt for huntingtin function: interaction partners tell many different stories

21 March 2017

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Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS

21 March 2017

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A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF

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Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

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The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes

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Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms

28 September 2017

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Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Multimodal MRI analysis of the corpus callosum reveals white matter differences in presymptomatic and early Huntington's disease.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.

28 September 2017

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Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation

28 September 2017

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28 September 2017

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Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features

28 September 2017

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Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

28 September 2017

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28 September 2017

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28 September 2017

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Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.

28 September 2017

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"Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system

28 September 2017

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28 September 2017

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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

28 September 2017

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Huntingtin-protein interactions and the pathogenesis of Huntington's disease

28 September 2017

1 reference

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Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis

28 September 2017

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28 September 2017

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Quantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosis

28 September 2017

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Peroxisome-proliferator-activated receptor gamma coactivator 1 α contributes to dysmyelination in experimental models of Huntington's disease

28 September 2017

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In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease

31 May 2018

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31 May 2018

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31 May 2018

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31 May 2018

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Motor skill learning requires active central myelination.

31 May 2018

1 reference

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MRI measures of corpus callosum iron and myelin in early Huntington's disease.

28 November 2018

1 reference

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Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis.

28 November 2018

1 reference

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Diffusion tensor imaging in Huntington's disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits

28 November 2018

1 reference

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Atrophy and degeneration in sciatic nerve of presymptomatic mice carrying the Huntington's disease mutation

28 November 2018

1 reference

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Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4366619

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4366619

Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4366619

Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4366619

Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.

28 November 2018

1 reference

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Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25789755

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEURON.2015.02.026

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25789755%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25789755%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25789755%20AND%20SRC:MED&resulttype=core&format=json