Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration (Q27027490)

Daniel A. Linseman

series ordinal

2

1 reference

language of work or name

1 reference

2014

1 reference

Frontiers in Cellular Neuroscience

published in

1 reference

volume

8

1 reference

page(s)

314

1 reference

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

cites work

1 reference

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Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)

21 March 2017

1 reference

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Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

21 March 2017

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SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

21 March 2017

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 March 2017

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ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth

21 March 2017

1 reference

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Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease

21 March 2017

1 reference

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Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10

21 March 2017

1 reference

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A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Characterization of RAC3, a novel member of the Rho family

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

rac, a novel ras-related family of proteins that are botulinum toxin substrates

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rho GTPases and the actin cytoskeleton

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons

21 March 2017

1 reference

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Generation and characterization of Rac3 knockout mice.

21 March 2017

1 reference

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Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

A radial glia-specific role of RhoA in double cortex formation

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Alsin/Rac1 signaling controls survival and growth of spinal motoneurons

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Evidence for the involvement of Tiam1 in axon formation

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Mammalian Rho GTPases: new insights into their functions from in vivo studies

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rho GTPases in neuronal morphogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Excitotoxicity and stroke: identifying novel targets for neuroprotection.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Neuronal Rac1 is required for learning-evoked neurogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rac1 selective activation improves retina ganglion cell survival and regeneration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rho GTPase function in development: how in vivo models change our view

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Molecular signatures of amyotrophic lateral sclerosis disease progression in hind and forelimb muscles of an SOD1(G93A) mouse model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Altered apoptotic responses in neurons lacking RhoB GTPase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Actin polymerization is essential for myelin sheath fragmentation during Wallerian degeneration.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

The rho GTPase Rac1 is required for proliferation and survival of progenitors in the developing forebrain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Spatio-temporal Rho GTPase signaling - where are we now?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Control of postnatal apoptosis in the neocortex by RhoA-subfamily GTPases determines neuronal density

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Targeting a dominant negative rho kinase to neurons promotes axonal outgrowth and partial functional recovery after rat rubrospinal tract lesion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

p21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Cystamine prevents ischemia-reperfusion injury by inhibiting polyamination of RhoA.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Diverse roles of Rho family GTPases in neuronal development, survival, and death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Redox modifier genes in amyotrophic lateral sclerosis in mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Kalirin is under-expressed in Alzheimer's disease hippocampus.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rho GTPases, dendritic structure, and mental retardation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Signalling and crosstalk of Rho GTPases in mediating axon guidance.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rac GTPases control axon growth, guidance and branching

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

GTPase RhoB: an early predictor of neuronal death after transient focal ischemia in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

HMG-CoA reductase inhibitor induces a transient activation of high affinity nerve growth factor receptor, trk, and morphological differentiation with fatal outcome in PC12 cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

The role of local actin instability in axon formation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

An essential role for Rac/Cdc42 GTPases in cerebellar granule neuron survival

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurones

31 May 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of Rho and ROCK inhibitors on neurite outgrowth and myelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Effect of focal cerebral infarctions on lesional RhoA and RhoB expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

The protective effect of Rho-associated kinase inhibitor on aluminum-induced neurotoxicity in rat cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Immunohistochemical analysis of protein expression after middle cerebral artery occlusion in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

alpha Pix enhances mutant huntingtin aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Rac function and regulation during Drosophila development.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Protein kinase and protein phosphatase expression in the central nervous system of G93A mSOD over-expressing mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

p21-Activated kinase-1 is necessary for depolarization-mediated neuronal survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

A role for RhoB in synaptic plasticity and the regulation of neuronal morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Fibrillar amyloid-β1-42 modifies actin organization affecting the cofilin phosphorylation state: a role for Rac1/cdc42 effector proteins and the slingshot phosphatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Abeta1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Oral treatment with the NADPH oxidase antagonist apocynin mitigates clinical and pathological features of parkinsonism in the MPTP marmoset model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Rotenone-induced toxicity is mediated by Rho-GTPases in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Rac1 is required for the formation of three germ layers during gastrulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Rac1 regulates neuronal polarization through the WAVE complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

ALS predisposition modifiers: knock NOX, who's there? SOD1 mice still are.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Fasudil hydrochloride protects neurons in rat hippocampal CA1 region through inhibiting GluR6-MLK3-JNKs signal pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Ischemic preconditioning negatively regulates plenty of SH3s-mixed lineage kinase 3-Rac1 complex and c-Jun N-terminal kinase 3 signaling via activation of Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Brain-derived neurotrophic factor inhibits phenylalanine-induced neuronal apoptosis by preventing RhoA pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00314

Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rho kinase inhibition enhances axonal regeneration in the injured CNS.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Rac1 mediates collapsin-1-induced growth cone collapse

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187614

Statins induce differentiation and cell death in neurons and astroglia

28 November 2018

1 reference

12 December 2020

Co-aggregation of RNA binding proteins in ALS spinal motor neurons: evidence of a common pathogenic mechanism

1 reference

12 December 2020

Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation

1 reference

12 December 2020

Essential role of Rac1 and Rac3 GTPases in neuronal development

1 reference

12 December 2020

Identifiers

DOI

10.3389/FNCEL.2014.00314

1 reference

1380065

1380065

1 reference

1 reference

1 reference