Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis. (Q46872819)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

2 March 2020

main subject

microglia

0 references

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Paul Lingor

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

René Günther

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Jan C Koch

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

6

Kim-Ann Saal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

5

Alexander Balck

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

7

Elisabeth Barski

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

13

Michael W Sereda

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

author name string

Martin Suhr

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Johannes Jansen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Tobias Nientied

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Alexander A Götz

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Bernhard K Mueller

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Jochen H Weishaupt

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Mathias Bähr

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Uwe-Karsten Hanisch

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

publication date

6 December 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

62

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

page(s)

217-232

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24311453%20AND%20SRC:MED&resulttype=core&format=json

Altered astrocytic response to activation in SOD1(G93A) mice and its implications on amyotrophic lateral sclerosis pathogenesis

2 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

ALS: a disease of motor neurons and their nonneuronal neighbors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

The pharmacology and mechanism of action of riluzole

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Axonal degeneration in motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Programmed cell death in animal development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Changing face of microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Proteins in microglial activation--inputs and outputs by subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Microglia in ALS: the good, the bad, and the resting

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Glutamate receptors, neurotoxicity and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Spinal anterior horn has the capacity to self-regenerate in amyotrophic lateral sclerosis model mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Rho kinase, a promising drug target for neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Antisense oligonucleotide therapy for neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

The human G93A SOD1 phenotype closely resembles sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Astrogliosis in amyotrophic lateral sclerosis: role and therapeutic potential of astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021

Neuromuscular function impairment is not caused by motor neurone loss in FALS mice: an electromyographic study

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021

ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021

CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021

The clinical effectiveness and cost-effectiveness of riluzole for motor neurone disease: a rapid and systematic review

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021

The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021

Abnormal regenerative responses and impaired axonal outgrowth after nerve crush in TDP-43 transgenic mouse models of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021

Increased cytotoxic potential of microglia from ALS-transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021

Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021

Functional abnormalities in P0-deficient mice resemble human hereditary neuropathies linked to P0 gene mutations

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22601

7 January 2021