RIP2 activity in inflammatory disease and implications for novel therapeutics (Q27025050)

F. Cominelli

series ordinal

2

1 reference

D. W. Abbott

series ordinal

3

1 reference

language of work or name

1 reference

November 2013

1 reference

Journal of Leukocyte Biology

published in

1 reference

volume

94

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issue

5

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page(s)

927-32

1 reference

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

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Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK

21 March 2017

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Role for erbin in bacterial activation of Nod2

21 March 2017

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A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling

21 March 2017

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The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

21 March 2017

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 March 2017

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 March 2017

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 March 2017

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 March 2017

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Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

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Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

21 March 2017

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 March 2017

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Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

21 March 2017

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An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways

21 March 2017

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 March 2017

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The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

21 March 2017

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The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

21 March 2017

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Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

21 March 2017

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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

21 March 2017

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Inflammatory bowel disease

7 April 2017

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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

7 April 2017

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An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

7 April 2017

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Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2.

7 April 2017

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NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.

28 September 2017

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A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling

28 September 2017

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Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components

28 September 2017

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The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment

28 September 2017

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Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.

28 September 2017

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IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling

28 September 2017

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Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease

28 September 2017

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Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation

28 September 2017

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Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors

28 September 2017

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28 September 2017

Blau syndrome revisited.

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Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signaling

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800061

Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections

28 September 2017

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A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment

28 September 2017

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Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity

28 September 2017

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Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.

28 September 2017

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Deubiquitinases in the regulation of NF-κB signaling

28 September 2017

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ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis

28 September 2017

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Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.

28 September 2017

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Nod2 is required for the regulation of commensal microbiota in the intestine

28 September 2017

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XIAP mediates NOD signaling via interaction with RIP2

28 September 2017

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The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responses

28 September 2017

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Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

28 September 2017

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NOD-like receptors: role in innate immunity and inflammatory disease

28 September 2017

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Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis

28 September 2017

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Intracellular NOD-like receptors in innate immunity, infection and disease

28 September 2017

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Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide

28 September 2017

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NOD2/CARD15 disease associations other than Crohn's disease

28 September 2017

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Nod-like proteins in immunity, inflammation and disease

28 September 2017

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Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

28 September 2017

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Advances and perspectives in the genetics of inflammatory bowel diseases

28 September 2017

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Inhibition of RIP2/RIck/CARDIAK activity by pyridinyl imidazole inhibitors of p38 MAPK.

28 September 2017

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NOD1 variation, immunoglobulin E and asthma.

28 September 2017

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Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease.

28 September 2017

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Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

28 September 2017

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Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease

28 September 2017

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Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

28 September 2017

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Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.

28 September 2017

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The molecular classification of the clinical manifestations of Crohn's disease

28 September 2017

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A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways.

28 September 2017

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The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation

31 May 2018

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Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation

31 May 2018

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Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains

31 May 2018

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21 January 2018

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Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohn's disease

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21 January 2018

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The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

21 January 2018

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