The black box illuminated: signals and signaling (Q27024571)

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13 May 2020

3

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13 May 2020

4

Stuart H Yuspa

1 reference

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13 May 2020

author name string

Francesca Mascia

series ordinal

1

2 references

Crossref

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6340394&resulttype=core&format=json

13 May 2020

Mitchell Denning

series ordinal

2

2 references

Crossref

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6340394&resulttype=core&format=json

13 May 2020

language of work or name

1 reference

March 2012

1 reference

Journal of Investigative Dermatology

published in

2 references

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13 May 2020

volume

132

2 references

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13 May 2020

page(s)

811-819

1 reference

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13 May 2020

issue

3 Pt 2

2 references

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Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain

13 May 2020

cites work

1 reference

12 December 2020

Transgenic mice overexpressing protein kinase Cdelta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

1 reference

12 December 2020

Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion

1 reference

12 December 2020

Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump

1 reference

12 December 2020

Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters.

1 reference

12 December 2020

Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers

1 reference

12 December 2020

Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma.

1 reference

12 December 2020

IKKalpha controls formation of the epidermis independently of NF-kappaB.

1 reference

12 December 2020

Incidence of cancer among patients with hidradenitis suppurativa

1 reference

12 December 2020

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

1 reference

12 December 2020

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

1 reference

12 December 2020

Ca2+-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells

1 reference

12 December 2020

Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation

1 reference

12 December 2020

Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms

1 reference

12 December 2020

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

1 reference

12 December 2020

Notch1 functions as a tumor suppressor in mouse skin

1 reference

12 December 2020

c-Jun regulates eyelid closure and skin tumor development through EGFR signaling

1 reference

12 December 2020

Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation

1 reference

12 December 2020

Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes

1 reference

12 December 2020

Ultraviolet Light Irradiation Increases Cellular Diacylglycerol and Induces Translocation of Diacylglycerol Kinase in Murine Keratinocytes

1 reference

12 December 2020

Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells

1 reference

12 December 2020

1 reference

12 December 2020

Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation

1 reference

12 December 2020

Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms

1 reference

12 December 2020

The role of the calcium-sensing receptor in epidermal differentiation

1 reference

12 December 2020

gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis

1 reference

12 December 2020

Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease

1 reference

12 December 2020

Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo

1 reference

12 December 2020

ERK1/2 regulates epidermal chemokine expression and skin inflammation

1 reference

12 December 2020

Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment

1 reference

12 December 2020

PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.

1 reference

12 December 2020

Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?

1 reference

12 December 2020

Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin.

1 reference

12 December 2020

The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas

1 reference

12 December 2020

Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function

1 reference

12 December 2020

Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation

1 reference

12 December 2020

Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells

1 reference

12 December 2020

Expression of voltage-gated calcium channel subunit alpha1C in epidermal keratinocytes and effects of agonist and antagonists of the channel on skin barrier homeostasis.

1 reference

12 December 2020

Phosphotyrosine interactome of the ErbB-receptor kinase family

1 reference

12 December 2020

A comprehensive pathway map of epidermal growth factor receptor signaling

1 reference

12 December 2020

Mechanisms of cutaneous toxicities to EGFR inhibitors.

1 reference

12 December 2020

Canonical notch signaling functions as a commitment switch in the epidermal lineage

1 reference

12 December 2020

The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation.

1 reference

12 December 2020

Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3.

1 reference

12 December 2020

SnapShot: notch signaling pathway

1 reference

12 December 2020

Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function

1 reference

12 December 2020

Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes.

1 reference

12 December 2020

Murine vibrissae cultured in serum-free medium reinitiate anagen

1 reference

12 December 2020

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities

1 reference

12 December 2020

Tumor immune escape by the loss of homeostatic chemokine expression.

1 reference

12 December 2020

Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes

1 reference

12 December 2020

ORIGINAL ARTICLE: Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis

1 reference

12 December 2020

Multiple roles of Notch signaling in the regulation of epidermal development.

1 reference

12 December 2020

Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival

1 reference

12 December 2020

Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity

1 reference

12 December 2020

Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology

1 reference

12 December 2020

Multiple roles of phosphoinositide-specific phospholipase C isozymes

1 reference

12 December 2020

The ADAM metalloproteinases

1 reference

12 December 2020

Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology

1 reference

12 December 2020

Endocytosis and intracellular trafficking of ErbBs

1 reference

12 December 2020

Changes in inositol phosphate metabolism are associated with terminal differentiation and neoplasia in mouse keratinocytes

1 reference

12 December 2020

Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis

1 reference

12 December 2020

PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study

1 reference

12 December 2020

The canonical Notch signaling pathway: unfolding the activation mechanism

1 reference

12 December 2020

Erk1/2 MAP kinases are required for epidermal G2/M progression

1 reference

12 December 2020

Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.

1 reference

12 December 2020

Restoration of BRAK / CXCL14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head and neck squamous cell carcinoma

1 reference

12 December 2020

Capacitative calcium entry: from concept to molecules

1 reference

12 December 2020

EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo

1 reference

12 December 2020

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells

1 reference

12 December 2020

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin

1 reference

12 December 2020

The epidermal Ca(2+) gradient: Measurement using the phasor representation of fluorescent lifetime imaging

1 reference

12 December 2020

EGF receptor activation by GPCRs: an universal pathway reveals different versions

1 reference

12 December 2020

TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation

1 reference

12 December 2020

PKC-delta and -eta, MEKK-1, MEK-6, MEK-3, and p38-delta are essential mediators of the response of normal human epidermal keratinocytes to differentiating agents

1 reference

12 December 2020

The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature

1 reference

12 December 2020

Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis

1 reference

12 December 2020

Gamma-secretase gene mutations in familial acne inversa

1 reference

12 December 2020

Darier disease : a disease model of impaired calcium homeostasis in the skin

1 reference

12 December 2020

Major translocation of calcium upon epidermal barrier insult: imaging and quantification via FLIM/Fourier vector analysis

1 reference

12 December 2020

Calcineurin signaling as a negative determinant of keratinocyte cancer stem cell potential and carcinogenesis

1 reference

12 December 2020

1 reference

12 December 2020

Analysis of CaM-kinase signaling in cells

1 reference

12 December 2020

Epidermal growth factor receptor inhibition augments the expression of MHC class I and II genes

1 reference

12 December 2020

Early signals for keratinocyte differentiation: role of Ca2+-mediated inositol lipid metabolism in normal and neoplastic epidermal cells

1 reference

12 December 2020

Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro

1 reference

12 December 2020

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

1 reference

12 December 2020

The role of protein kinase C in cell surface signal transduction and tumour promotion

2 references

12 December 2020

Crossref

https://api.crossref.org/works/10.1038%2FJID.2011.406

7 January 2021

inferred from DOI database lookup

Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure

1 reference

12 December 2020

Loss of protein kinase C delta from human HaCaT keratinocytes upon ras transfection is mediated by TGF alpha

1 reference

12 December 2020

Identification of a calcium-inducible, epidermal-specific regulatory element in the 3'-flanking region of the human keratin 1 gene

1 reference

12 December 2020

Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium.

1 reference

12 December 2020

Chelation of intracellular Ca2+ inhibits murine keratinocyte differentiation in vitro

1 reference

12 December 2020

Keratinocyte differentiation is associated with changes in the expression and regulation of phospholipase C isoenzymes

1 reference

12 December 2020

Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta.

1 reference

12 December 2020

Inhibitors of the intracellular Ca(2+)-ATPase in cultured mouse keratinocytes reveal components of terminal differentiation that are regulated by distinct intracellular Ca2+ compartments.

1 reference

12 December 2020

Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta

1 reference

12 December 2020

Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development

1 reference

12 December 2020

Keratinocyte K+ channels mediate Ca2+-induced differentiation

1 reference

12 December 2020

Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters.

1 reference

12 December 2020

Identifiers

DOI

10.1038/JID.2011.406

2 references

Consolidated OpenCitations Corpus – April 2017

2432349

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6340394&resulttype=core&format=json

Dimensions Publication ID

13 May 2020

1033434642

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Fatcat ID

release_rwzxxgrsjrfnbib5wnbk4akgb4

0 references

2432349

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6340394&resulttype=core&format=json

13 May 2020

2 references

Consolidated OpenCitations Corpus – April 2017

2432349

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6340394&resulttype=core&format=json