Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation (Q28590384)

GOA release 2020-03-11

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Oliver Kudlacek

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Oliver Kudlacek

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31 January 2017

Ingvar Ferby

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31 January 2017

Markus Reschke

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31 January 2017

Pjotr Knyazev

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Guido Pantè

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Kerstin Amann

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Wolfgang Sommergruber

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Norbert Kraut

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31 January 2017

Axel Ullrich

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31 January 2017

Rüdiger Klein

Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stre

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31 January 2017

language of work or name

English

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publication date

1 May 2006

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31 January 2017

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568–573

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Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain

21 January 2018

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Mig-6 is a negative regulator of the epidermal growth factor receptor signal

21 January 2018

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Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation

21 January 2018

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Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control

21 January 2018

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Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function

21 January 2018

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Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth

21 January 2018

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Feedback inhibition by RALT controls signal output by the ErbB network

21 January 2018

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Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation

21 January 2018

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Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype

21 January 2018

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The cornified envelope: a model of cell death in the skin

21 January 2018

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Role of integrins in regulating epidermal adhesion, growth and differentiation

21 January 2018

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Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype.

21 January 2018

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Sustained activation of the mitogen-activated protein kinase pathway. A mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration.

21 January 2018

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The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

21 January 2018

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Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis

21 January 2018

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Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease

21 January 2018

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Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumor-specific genes

21 January 2018

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Prognostic value of chromosome 1p allelic loss in colon cancer

21 January 2018

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ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells

21 January 2018

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Changes in keratin gene expression during terminal differentiation of the keratinocyte

21 January 2018

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7 January 2021

Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes

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7 January 2021

Regulation of wound healing by growth factors and cytokines

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7 January 2021

Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer

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7 January 2021