Regulators of synaptic transmission: roles in the pathogenesis and treatment of epilepsy (Q26859135)

Kim L. Powell

series ordinal

2

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Terence J. O’Brien

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3

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language of work or name

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December 2012

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53 Suppl 9

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PubMed

page(s)

41-58

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Presynaptic inhibition of corticothalamic feedback by metabotropic glutamate receptors

PubMed

cites work

1 reference

Metabotropic glutamate receptors as a strategic target for the treatment of epilepsy

21 January 2018

1 reference

Unique presynaptic and postsynaptic roles of Group II metabotropic glutamate receptors in the modulation of thalamic network activity.

21 January 2018

1 reference

Differential response dynamics of corticothalamic glutamatergic synapses in the lateral geniculate nucleus and thalamic reticular nucleus.

21 January 2018

1 reference

In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders

21 January 2018

1 reference

Perturbation of syndapin/PACSIN impairs synaptic vesicle recycling evoked by intense stimulation.

21 January 2018

1 reference

Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis

21 January 2018

1 reference

Synaptic kainate receptors in interplay with INaP shift the sparse firing of dentate granule cells to a sustained rhythmic mode in temporal lobe epilepsy.

21 January 2018

1 reference

Cognitive enhancing effects of ghrelin receptor agonists

21 January 2018

1 reference

Hippocampal gene expression analysis using the ORESTES methodology shows that homer 1a mRNA is upregulated in the acute period of the pilocarpine epilepsy model

21 January 2018

1 reference

Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons

21 January 2018

1 reference

Neuropeptide Y and limbic seizures.

21 January 2018

1 reference

Neuropeptide Y and epilepsy: recent progress, prospects and controversies.

21 January 2018

1 reference

Interneuron Diversity series: Interneuronal neuropeptides--endogenous regulators of neuronal excitability

21 January 2018

1 reference

Selective loss of AMPA receptors at corticothalamic synapses in the epileptic stargazer mouse.

21 January 2018

1 reference

Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests

21 January 2018

1 reference

Entorhinal cortex involvement in human mesial temporal lobe epilepsy: an electrophysiologic and volumetric study.

21 January 2018

1 reference

21 January 2018

Seletracetam (UCB 44212)

1 reference

Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4

21 January 2018

1 reference

Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X).

21 January 2018

1 reference

On the Role of Somatostatin in Seizure Control: Clues from the Hippocampus

21 January 2018

1 reference

BDNF and epilepsy: too much of a good thing?

21 January 2018

1 reference

Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse.

21 January 2018

1 reference

Adenosine dysfunction in epilepsy

21 January 2018

1 reference

A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice

21 January 2018

1 reference

Efficacy and Safety of Remacemide versus Carbamazepine in Newly Diagnosed Epilepsy: Comparison by Sequential Analysis.

21 January 2018

1 reference

Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities

21 January 2018

1 reference

Molecular characterization of the ligand-receptor interaction of the neuropeptide Y family

21 January 2018

1 reference

Cell biology of the ghrelin receptor

21 January 2018

1 reference

Regulation of Ghrelin Secretion and Action

21 January 2018

1 reference

Differential distribution of dynamin isoforms in mammalian cells

21 January 2018

1 reference

Seizure-induced changes in neuropeptide Y-containing cortical neurons: Potential role for seizure threshold and epileptogenesis.

21 January 2018

1 reference

Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study

21 January 2018

1 reference

A novel anti-epileptic agent, perampanel, selectively inhibits AMPA receptor-mediated synaptic transmission in the hippocampus.

21 January 2018

1 reference

Pre- and post-synaptic functions of kainate receptors at glutamate and GABA synapses in the rat entorhinal cortex.

21 January 2018

1 reference

SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis

21 January 2018

1 reference

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68.

21 January 2018

1 reference

Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies.

21 January 2018

1 reference

Opposite changes in glutamatergic and GABAergic transmission underlie the diffuse hyperexcitability of synapsin I-deficient cortical networks

21 January 2018

1 reference

Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95

21 January 2018

1 reference

The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles

21 January 2018

1 reference

A nomenclature for ligand-gated ion channels

21 January 2018

1 reference

Pharmacology and functions of metabotropic glutamate receptors

21 January 2018

1 reference

Kainate receptors coming of age: milestones of two decades of research

21 January 2018

1 reference

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

21 January 2018

1 reference

Plasticity of somatostatin and somatostatin sst2A receptors in the rat dentate gyrus during kindling epileptogenesis

21 January 2018

1 reference

Somatostatin receptor type 2 undergoes plastic changes in the human epileptic dentate gyrus

21 January 2018

1 reference

Role of distinct NMDA receptor subtypes at central synapses

21 January 2018

1 reference

Synaptic vesicle protein 2 enhances release probability at quiescent synapses

21 January 2018

1 reference

Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug

21 January 2018

1 reference

The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits

21 January 2018

1 reference

Regulation of AMPA receptors by transmembrane accessory proteins

21 January 2018

1 reference

A possible association of responsiveness to adrenocorticotropic hormone with specific GRIN1 haplotypes in infantile spasms

21 January 2018

1 reference

Losigamone decreases spontaneous synaptic activity in cultured hippocampal neurons

21 January 2018

1 reference

Changes in AMPA receptor binding and subunit messenger RNA expression in hippocampus and cortex in the pentylenetetrazole-induced 'kindling' model of epilepsy

21 January 2018

1 reference

The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors

21 January 2018

1 reference

Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes

21 January 2018

1 reference

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis.

21 January 2018

1 reference

Analysis of dynamin isoforms in mammalian brain: dynamin-1 expression is spatially and temporally regulated during postnatal development

21 January 2018

1 reference

SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function

21 January 2018

1 reference

A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis

21 January 2018

1 reference

Metabotropic glutamate receptors.

21 January 2018

1 reference

Metabotropic glutamate 1 receptor: current concepts and perspectives.

21 January 2018

1 reference

Distribution of NPY receptors in the hypothalamus

21 January 2018

1 reference

The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology

21 January 2018

1 reference

Distinct functional roles of subunits within the heteromeric kainate receptor

21 January 2018

1 reference

Multiple interaction sites of galnon trigger its biological effects

21 January 2018

1 reference

Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

21 January 2018

1 reference

Identification of new epilepsy treatments: issues in preclinical methodology

21 January 2018

1 reference

Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy

21 January 2018

1 reference

Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat

21 January 2018

1 reference

Subtypes of receptors for neuropeptide Y: implications for the targeting of therapeutics

21 January 2018

1 reference

Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2).

21 January 2018

1 reference

Metabotropic glutamate receptors differentially regulate GABAergic inhibition in thalamus.

21 January 2018

1 reference

Interneurons are the local targets of hippocampal inhibitory cells which project to the medial septum.

21 January 2018

1 reference

Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy

21 January 2018

1 reference

Surface traffic in synaptic membranes

21 January 2018

1 reference

Different roles of C-terminal cassettes in the trafficking of full-length NR1 subunits to the cell surface

21 January 2018

1 reference

Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro

21 January 2018

1 reference

Regulation of brain-derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol-induced epileptic seizures.

21 January 2018

1 reference

Differential localization and regulation of stargazin-like protein, gamma-8 and stargazin in the plasma membrane of hippocampal and cortical neurons

21 January 2018

1 reference

BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF.

21 January 2018

1 reference

The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits

21 January 2018

1 reference

Kainate receptors: pharmacology, function and therapeutic potential

21 January 2018

1 reference

SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family.

21 January 2018

1 reference

SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release

21 January 2018

1 reference

SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development

21 January 2018

1 reference

Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam

21 January 2018

1 reference

Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors

21 January 2018

1 reference

Neurotrophin signal transduction in the nervous system

21 January 2018

1 reference

vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis.

21 January 2018

1 reference

Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins

21 January 2018

1 reference

Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg

21 January 2018

1 reference

Synapsin utilization differs among functional classes of synapses on thalamocortical cells.

21 January 2018

1 reference

Organization and regulation of proteins at synapses

21 January 2018

1 reference

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.

21 January 2018

1 reference

Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I

21 January 2018

1 reference

Altered expression of NPY-Y1 receptors in kainic acid induced epilepsy in rats.

21 January 2018

1 reference

Depression of GABAergic input to identified hippocampal neurons by group III metabotropic glutamate receptors in the rat.

21 January 2018

1 reference

Tolerability and safety of perampanel: two randomized dose-escalation studies.

21 January 2018

1 reference

A genetic switch for epilepsy in adult mice.

21 January 2018

1 reference

Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy.

21 January 2018

1 reference

The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit.

21 January 2018

1 reference

Reciprocal up- and down-regulation of BDNF mRNA in tetanus toxin-induced epileptic focus and inhibitory surround in cerebral cortex.

21 January 2018

1 reference

Molecular recognition of the NPY hormone family by their receptors

21 January 2018

1 reference

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

21 January 2018

1 reference

Role of the Y5 neuropeptide Y receptor in limbic seizures

21 January 2018

1 reference

Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy

21 January 2018

1 reference

Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy.

21 January 2018

1 reference

Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors

21 January 2018

1 reference

Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus

21 January 2018

1 reference

Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling

21 January 2018

1 reference

Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus

21 January 2018

1 reference

Molecular signaling mechanisms underlying epileptogenesis

21 January 2018

1 reference

Molecular targets for antiepileptic drug development

21 January 2018

1 reference

Tyrosine phosphorylation of synapsin I by Src regulates synaptic-vesicle trafficking

21 January 2018

1 reference

Clinical potential of neuropeptide Y receptor ligands in the treatment of epilepsy

21 January 2018

1 reference

Differential synaptic distribution of AMPA receptor subunits in the ventral posterior and reticular thalamic nuclei of the rat.

21 January 2018

1 reference

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

21 January 2018

1 reference

A molecular determinant for submillisecond desensitization in glutamate receptors

21 January 2018

1 reference

Endogenous adenosine induces NMDA receptor-independent persistent epileptiform discharges in dorsal and ventral hippocampus via activation of A2 receptors.

21 January 2018

1 reference

Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.

21 January 2018

1 reference

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

21 January 2018

1 reference

Neuropeptide Y overexpression using recombinant adeno-associated viral vectors.

21 January 2018

1 reference

Electrophysiological effects of the anticonvulsant remacemide hydrochloride and its metabolite ARL 12495AA on rat CA1 hippocampal neurons in vitro.

21 January 2018

1 reference

Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats.

21 January 2018

1 reference

A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents

21 January 2018

1 reference

Somatostatin and its receptor family

21 January 2018

1 reference

Neuropeptide Y: the universal soldier

21 January 2018

1 reference

Felbamate in epilepsy therapy: evaluating the risks

21 January 2018

1 reference

Homeostatic plasticity and NMDA receptor trafficking

21 January 2018

1 reference

Ghrelin: an emerging new anticonvulsant neuropeptide.

21 January 2018

1 reference

Kindling-induced overexpression of Homer 1A and its functional implications for epileptogenesis

21 January 2018

1 reference

Pilocarpine-induced seizure-like activity with increased BNDF and neuropeptide Y expression in organotypic hippocampal slice cultures

21 January 2018

1 reference

Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors

21 January 2018

1 reference

Functional downregulation of GluR2 in piriform cortex of kindled animals

21 January 2018

1 reference

Syndapin isoforms participate in receptor-mediated endocytosis and actin organization

21 January 2018

1 reference

Overlapping role of dynamin isoforms in synaptic vesicle endocytosis

21 January 2018

1 reference

Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus

21 January 2018

1 reference

Vesicle scission: dynamin.

21 January 2018

1 reference

Neuropeptide Y and epilepsy: varying effects according to seizure type and receptor activation

21 January 2018

1 reference

Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.

21 January 2018

1 reference

Kainate receptor modulation of GABA release involves a metabotropic function.

21 January 2018

1 reference

Revisiting AMPA receptors as an antiepileptic drug target

21 January 2018

1 reference

Anticonvulsant activity of a nonpeptide galanin receptor agonist

21 January 2018

1 reference

Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock.

21 January 2018

1 reference

Modulation of sensory inhibition in the ventrobasal thalamus via activation of group II metabotropic glutamate receptors by 2R,4R-aminopyrrolidine-2,4-dicarboxylate.

21 January 2018

1 reference

Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus

21 January 2018

1 reference

Clinical use of an herbal-derived compound (Huperzine A) to treat putative complex partial seizures in a dog.

21 January 2018

1 reference

Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors

21 January 2018

1 reference

Regulation of ion channel/neurotransmitter receptor function by RNA editing

21 January 2018

1 reference

Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus

21 January 2018

1 reference

The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention

21 January 2018

1 reference

Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities

21 January 2018

1 reference

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

21 January 2018

1 reference

Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP.

21 January 2018

1 reference

The effect of losigamone (AO-33) on electrical activity and excitatory amino acid release in mouse cortical slices

21 January 2018

1 reference

Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP

21 January 2018

1 reference

Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): implications for an environmental basis of neurodevelopmental disorders

21 January 2018

1 reference

RNA editing of Kv1.1 channels may account for reduced ictogenic potential of 4-aminopyridine in chronic epileptic rats

21 January 2018

1 reference

Neuropeptide Y suppresses absence seizures in a genetic rat model.

21 January 2018

1 reference

The AMPAR subunit GluR2: still front and center-stage

21 January 2018

1 reference

Demonstration of long-range GABAergic connections distributed throughout the mouse neocortex

21 January 2018

1 reference

Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins

21 January 2018

1 reference

Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses

21 January 2018

1 reference

Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs.

21 January 2018

1 reference

Glutamate receptor ion channels: structure, regulation, and function

21 January 2018

1 reference

Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain

21 January 2018

1 reference

Sacred disease secrets revealed: the genetics of human epilepsy

21 January 2018

1 reference

Characterization of sensory and corticothalamic excitatory inputs to rat thalamocortical neurones in vitro.

21 January 2018

1 reference

Synaptic activation of the group I metabotropic glutamate receptor mGlu1 on the thalamocortical neurons of the rat dorsal lateral geniculate nucleus in vitro.

21 January 2018

1 reference

Group II and III metabotropic glutamate receptors and the control of the nucleus reticularis thalami input to rat thalamocortical neurones in vitro

21 January 2018

1 reference

Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy

21 January 2018

1 reference

Focal administration of neuropeptide Y into the S2 somatosensory cortex maximally suppresses absence seizures in a genetic rat model.

21 January 2018

1 reference

Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy

21 January 2018

1 reference

Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate.

21 January 2018

1 reference

Functional changes in somatostatin and neuropeptide Y containing neurons in the rat hippocampus in chronic models of limbic seizures.

21 January 2018

1 reference

Neuropeptide Y: emerging evidence for a functional role in seizure modulation.

21 January 2018

1 reference

Somatostatinergic systems in brain: networks and functions

21 January 2018

1 reference

The synaptic vesicle glycoprotein 2A ligand levetiracetam inhibits presynaptic Ca2+ channels through an intracellular pathway

21 January 2018

1 reference

RNA editing (R/G site) and flip-flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients

21 January 2018

1 reference

CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus

21 January 2018

1 reference

21 January 2018

Brivaracetam (UCB 34714)

1 reference

Neuropeptide Y receptors: ligand binding and trafficking suggest novel approaches in drug development

21 January 2018

1 reference

SV2 acts via presynaptic calcium to regulate neurotransmitter release.

21 January 2018

1 reference

The cognitive and psychomotor effects of remacemide and carbamazepine in newly diagnosed epilepsy.

21 January 2018

1 reference

Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization

21 January 2018

1 reference

Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models

21 January 2018

1 reference

Circadian integration of sleep-wake and feeding requires NPY receptor-expressing neurons in the mediobasal hypothalamus

21 January 2018

1 reference

Ghrelin: integrative neuroendocrine peptide in health and disease

21 January 2018

1 reference

Central functions of neuropeptide Y in mood and anxiety disorders

21 January 2018

1 reference

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1

21 January 2018

1 reference

Synaptic vesicle protein 2 binds adenine nucleotides

21 January 2018

1 reference

Cotrafficking of SV2 and synaptotagmin at the synapse.

21 January 2018

1 reference

Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex

21 January 2018

1 reference

TARPs and the AMPA receptor trafficking paradox.

21 January 2018

1 reference

Galanin reduces release of endogenous excitatory amino acids in the rat hippocampus.

21 January 2018

1 reference

Structural Domains Involved in the Regulation of Transmitter Release by Synapsins

21 January 2018

1 reference

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

21 January 2018

1 reference