The role and regulation of mTOR in T-lymphocyte function (Q26830161)

Xiao-Ping Zhong

series ordinal

2

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language of work or name

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June 2012

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Archivum Immunologiae et Therapiae Experimentalis

published in

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volume

60

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issue

3

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page(s)

173-81

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mTOR regulates memory CD8 T-cell differentiation

cites work

1 reference

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The TOR pathway comes of age

7 April 2017

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A complex interplay between Akt, TSC2 and the two mTOR complexes

7 April 2017

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

7 April 2017

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7 April 2017

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

7 April 2017

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

7 April 2017

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RasGRP links T-cell receptor signaling to Ras

7 April 2017

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7 April 2017

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TSC2 mediates cellular energy response to control cell growth and survival

7 April 2017

1 reference

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

7 April 2017

1 reference

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7 April 2017

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

7 April 2017

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

7 April 2017

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Properties and functions of diacylglycerol kinases

7 April 2017

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Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions

7 April 2017

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

7 April 2017

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Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid

7 April 2017

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Hierarchical phosphorylation of the translation inhibitor 4E-BP1

7 April 2017

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Critical roles of RasGRP1 for invariant NKT cell development

7 April 2017

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

7 April 2017

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

7 April 2017

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Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

7 April 2017

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

7 April 2017

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

7 April 2017

1 reference

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Regulation of T-cell survival and mitochondrial homeostasis by TSC1

7 April 2017

1 reference

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Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development

28 September 2017

1 reference

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The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

28 September 2017

1 reference

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The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Negative regulation of mTOR activation by diacylglycerol kinases

28 September 2017

1 reference

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Receptor signaling in immune cell development and function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

28 September 2017

1 reference

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Diacylglycerol kinases in immune cell function and self-tolerance

28 September 2017

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Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta

28 September 2017

1 reference

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Negative regulators in homeostasis of naïve peripheral T cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Effector and memory CTL differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Raptor and mTOR: Subunits of a Nutrient-Sensitive Complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Regulation of quiescence in lymphocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Novel "nonkinase" phorbol ester receptors: the C1 domain connection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Protein kinase C(theta) in T cell activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Regulation of RasGRP via a phorbol ester-responsive C1 domain.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Identification and characterization of a mitogen-activated S6 kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

S6K1 deficiency protects against apoptosis in hepatocytes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

The novel cyclophilin binding compound, sanglifehrin A, disassociates G1 cell cycle arrest from tolerance induction

31 May 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0171-4

Clonal anergy is maintained independently of T cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0171-4

Regulation of translation initiation by FRAP/mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0171-4

Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0171-4

The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0171-4

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00005-012-0171-4

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0171-4

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376380

LKLF: A transcriptional regulator of single-positive T cell quiescence and survival

28 November 2018

1 reference

12 December 2020

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1 reference

12 December 2020

Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation

1 reference

12 December 2020

A role for mammalian target of rapamycin in regulating T cell activation versus anergy

1 reference

12 December 2020

10.1007/S00005-012-0171-4

Identifiers

DOI

1 reference

Dimensions Publication ID

3030696

1034489858

0 references

3030696

1 reference

1 reference

1 reference