Multi-Facial, Non-Peptidic α-Helix Mimetics (Q26781261)

April 2022 Public Data File from Crossref

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The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Enhancement of α-Helix Mimicry by an α/β-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain Array

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Anatomy of hot spots in protein interfaces

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Synthesis and screening of small-molecule α-helix mimetic libraries targeting protein-protein interactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Design, solid-phase synthesis, and evaluation of a phenyl-piperazine-triazine scaffold as α-helix mimetics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

α-Helix mimetics: outwards and upwards

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Recapitulating the α-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein-protein interactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Inhibition of α-helix-mediated protein-protein interactions using designed molecules

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Design of triazole-stapled BCL9 α-helical peptides to target the β-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Targeting protein-protein and protein-nucleic acid interactions for anti-HIV therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Assessing helical protein interfaces for inhibitor design

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Protein-protein interaction networks and subnetworks in the biology of disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

BCL-2 family antagonists for cancer therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Pancreatic duodenal homeobox factor-1 and diabetes mellitus type 2 (review).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Synthetic non-peptide mimetics of alpha-helices

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Substituted 1,4-benzodiazepine-2,5-diones as alpha-helix mimetic antagonists of the HDM2-p53 protein-protein interaction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Protein surface recognition and proteomimetics: mimics of protein surface structure and function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Solid-phase synthesis of an A-B loop mimetic of the Cepsilon3 domain of human IgE: macrocyclization by Sonogashira coupling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Orthogonal functionalisation of α-helix mimetics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Amphipathic α-helix mimetics based on a 1,2-diphenylacetylene scaffold.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Probing the functional conformation of neuropeptide Y through the design and study of cyclic analogues

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Phospholipid catalysis of diabetic amyloid assembly

31 May 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

A highly stable short alpha-helix constrained by a main-chain hydrogen-bond surrogate

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Helical beta-peptide inhibitors of the p53-hDM2 interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

The design of dipeptide helical mimetics, Part I: the synthesis of 1,6-disubstituted indanes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

The design of dipeptide helical mimetics: The synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Oligophenylenaminones as scaffolds for α-helix mimicry.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Protein β-turn mimetics I. Design, synthesis, and evaluation in model cyclic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Double-sided α-helix mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Amphiphilic α-helix mimetics based on a benzoylurea scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4588149

Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic

28 November 2018

1 reference

12 December 2020

Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix

1 reference

12 December 2020

Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides

1 reference

12 December 2020

Novel amphiphilic alpha-helix mimetics based on a bis-benzamide scaffold

1 reference

12 December 2020

Enaminone-based mimics of extended and hydrophilic α-helices

1 reference

12 December 2020

An anthraquinone scaffold for putative, two-face Bim BH3 α-helix mimic

1 reference

12 December 2020

Two-face, two-turn α-helix mimetics based on a cross-acridine scaffold: analogues of the Bim BH3 domain

1 reference

12 December 2020

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

1 reference

12 December 2020

Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

1 reference

https://api.crossref.org/works/10.3390%2FBIOLOGY4030540

7 January 2021