Integrin-based therapeutics: biological basis, clinical use and new drugs (Q26773026)

Europe PubMed Central

title

Integrin-based therapeutics: biological basis, clinical use and new drugs (English)

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author name string

Klaus Ley

1

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Jesus Rivera-Nieves

2

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William J Sandborn

3

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Sanford Shattil

Nature Reviews Drug Discovery

4

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language of work or name

English

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publication date

March 2016

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published in

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volume

15

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issue

3

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page(s)

173-83

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cites work

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets

28 September 2017

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28 September 2017

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Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin

28 September 2017

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28 September 2017

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1 reference

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Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

A novel, orally active alpha 4 integrin antagonist, AJM300 prevents the development of experimental colitis induced by adoptive transfer of IL-10 deficient CD4(+) T cells in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

LAD-1/variant syndrome is caused by mutations in FERMT3.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Syk is required for integrin signaling in neutrophils

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Effects of abciximab and tirofiban on vitronectin receptors in human endothelial and smooth muscle cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4890615

Abciximab (ReoPro, chimeric 7E3 Fab) demonstrates equivalent affinity and functional blockade of glycoprotein IIb/IIIa and alpha(v)beta3 integrins

28 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.10

Contemporary use of glycoprotein IIb/IIIa inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.10

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.10

Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.10

MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.10

Neurological infections: the year of PML and influenza

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.10

A pilot study of treatment of active ulcerative colitis with natalizumab, a humanized monoclonal antibody to alpha-4 integrin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.10

Vedolizumab for the treatment of active ulcerative colitis: a randomized controlled phase 2 dose-ranging study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.10

Natalizumab: new drug. Multiple sclerosis: risky market approval

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26822833

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26822833

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD.2015.10

1 reference

Dimensions Publication ID

3804756

1040308214

0 references

Fatcat ID

release_ehfy25one5bmnjndapr2uroode

0 references

3804756

1 reference

1 reference

1 reference