In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform (Q26767210)

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Amanda L Placone

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Andrew D Wong

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Zinnia S Xu

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Peter C Searson

Frontiers in Bioengineering and Biotechnology

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language of work or name

English

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publication date

2016

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published in

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volume

4

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page(s)

12

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cites work

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28 September 2017

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28 September 2017

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28 September 2017

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Multicellular tumor spheroids: an underestimated tool is catching up again.

28 September 2017

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Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors

28 September 2017

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Lysophosphatidic acid (LPA) effects on endometrial carcinoma in vitro proliferation, invasion, and matrix metalloproteinase activity

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Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells

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Intravascular immunity: the host-pathogen encounter in blood vessels.

28 September 2017

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A novel mechanism for anti-EGFR antibody action involves chemokine-mediated leukocyte infiltration

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Deformability study of breast cancer cells using microfluidics

28 September 2017

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Investigation of MMP-2 and -9 in a highly invasive A431 tumor cell sub-line selected from a Boyden chamber assay.

28 September 2017

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Recent advances in three-dimensional multicellular spheroid culture for biomedical research

28 September 2017

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Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

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28 September 2017

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Rapid generation of single-tumor spheroids for high-throughput cell function and toxicity analysis

28 September 2017

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A parallel-gradient microfluidic chamber for quantitative analysis of breast cancer cell chemotaxis

28 September 2017

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Modulation of in vitro angiogenesis in a three-dimensional spheroidal coculture model for bone tissue engineering.

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Usefulness of collagen gel droplet embedded culture drug sensitivity testing in ovarian cancer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Measurement of macromolecular diffusion coefficients in human tumors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Diffusion and convection in collagen gels: implications for transport in the tumor interstitium

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Assessing tumor drug sensitivity by a new in vitro assay which preserves tumor heterogeneity and subpopulation interactions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Multicellular spheroids. A review on cellular aggregates in cancer research

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Multicell spheroids as a model for cell kinetic studies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

A microfluidic chip with a U-shaped microstructure array for multicellular spheroid formation, culturing and analysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Metabolic cooperation between mouse mammary tumor subpopulations in three-dimensional collagen gel cultures

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Examining the utility of patient-derived xenograft mouse models.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Tumor spheroid-based migration assays for evaluation of therapeutic agents.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

New dimensions in cell migration

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

An in vitro chemosensitivity test for solid human tumors using collagen gel droplet embedded cultures.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

A distinctive role for focal adhesion proteins in three-dimensional cell motility.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Formation of perfused, functional microvascular tubes in vitro.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Development and characterization of a spheroidal coculture model of endothelial cells and fibroblasts for improving angiogenesis in tissue engineering.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

MDA-MB-435 human breast carcinoma cell homo- and heterotypic adhesion under flow conditions is mediated in part by Thomsen-Friedenreich antigen-galectin-3 interactions.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Blood vessel maturation in a 3-dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Ultrastructural characterization of central neurocytomas using collagen gel culture.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Implantation of C6 astrocytoma spheroid into collagen type I gels: invasive, proliferative, and enzymatic characterizations.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751256

Interleukin-8 induces neutrophil transendothelial migration

28 November 2018

1 reference

12 December 2020

Characterization of the interaction between fibroblasts and tumor cells on a microfluidic co-culture device

1 reference

12 December 2020

Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells

1 reference

12 December 2020

In vitro cell migration and invasion assays

1 reference

12 December 2020

Role of extracellular matrix assembly in interstitial transport in solid tumors

1 reference

12 December 2020

Regulation of growth saturation and development of necrosis in EMT6/Ro multicellular spheroids by the glucose and oxygen supply

1 reference

12 December 2020

An in vitro chemosensitivity test for gastric cancer using collagen gel droplet embedded culture

1 reference

12 December 2020

E-selectin-mediated dynamic interactions of breast- and colon-cancer cells with endothelial-cell monolayers

1 reference

12 December 2020

The liquid overlay technique is the key to formation of co-culture spheroids consisting of primary osteoblasts, fibroblasts and endothelial cells

1 reference

12 December 2020

Growth of multicell spheroids in tissue culture as a model of nodular carcinomas

1 reference

12 December 2020

Inhibitory effect of tumor cell-derived lactic acid on human T cells

1 reference

12 December 2020

Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature

1 reference

12 December 2020

A simplified method for production and growth of multicellular tumor spheroids

1 reference

12 December 2020

Bacillus-Calmette-Guérin (BCG) and 3D tumors: an in vitro model for the study of adhesion and invasion

1 reference

12 December 2020

A modified Boyden chamber assay for tumor cell transendothelial migration in vitro

1 reference

12 December 2020

Transwell(®) invasion assays

1 reference

Crossref

https://api.crossref.org/works/10.3389%2FFBIOE.2016.00012

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.3389/FBIOE.2016.00012

1 reference

3887867

3887867

1 reference

1 reference

1 reference