Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. (Q30649677)

10

object named as

Eckhard Mandelkow

1 reference

20 September 2017

Katja Hochgräfe

1

1 reference

20 September 2017

Astrid Sydow

2

1 reference

20 September 2017

Dorthe Matenia

3

1 reference

20 September 2017

Daniela Cadinu

4

1 reference

20 September 2017

Stefanie Könen

5

1 reference

20 September 2017

Olga Petrova

6

1 reference

20 September 2017

Marcus Pickhardt

7

1 reference

20 September 2017

Petra Goll

8

1 reference

20 September 2017

Fabio Morellini

Acta Neuropathologica Communications

9

1 reference

20 September 2017

10 May 2015

1 reference

20 September 2017

1 reference

20 September 2017

3

1 reference

20 September 2017

25

1 reference

20 September 2017

Creative Commons Attribution 4.0 International

start time

10 May 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1186/s40478-015-0204-4

0 references

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Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models

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Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

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Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

28 July 2018

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Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

28 July 2018

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28 July 2018

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Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

28 July 2018

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

28 July 2018

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

28 July 2018

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Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

28 July 2018

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Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease.

28 July 2018

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Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

28 July 2018

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High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands

28 July 2018

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Control of memory formation through regulated expression of a CaMKII transgene

28 July 2018

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Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

28 July 2018

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28 July 2018

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

28 July 2018

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Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

28 July 2018

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Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.

28 July 2018

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Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

21 January 2018

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Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

21 January 2018

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The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

21 January 2018

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The DeltaK280 mutation in MAP tau favors exon 10 skipping in vivo.

21 January 2018

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Screening for inhibitors of tau polymerization

21 January 2018

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Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy

21 January 2018

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Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.

21 January 2018

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Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein

21 January 2018

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Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity.

21 January 2018

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Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish

21 January 2018

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Methylene blue administration fails to confer neuroprotection in two amyotrophic lateral sclerosis mouse models.

21 January 2018

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Pharmacokinetics and organ distribution of intravenous and oral methylene blue.

21 January 2018

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21 January 2018

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Global hairpin folding of tau in solution

21 January 2018

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Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation

21 January 2018

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Rhodanine-based tau aggregation inhibitors in cell models of tauopathy

21 January 2018

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Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

21 January 2018

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Memory facilitation by methylene blue: dose-dependent effect on behavior and brain oxygen consumption.

21 January 2018

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Inhibition of nitric oxide synthesis by methylene blue.

21 January 2018

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Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies.

21 January 2018

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Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

25 November 2018

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Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice

25 November 2018

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12 December 2020

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The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

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