Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig (Q24683936)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17428920%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17428920%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

main subject

endoplasmic reticulum

0 references

author

Arun Radhakrishnan

1

1 reference

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29 December 2019

5

Joseph L Goldstein

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17428920%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

author name string

Yukio Ikeda

2

1 reference

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29 December 2019

Hyock Joo Kwon

3

1 reference

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29 December 2019

Michael S Brown

4

1 reference

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29 December 2019

language of work or name

English

0 references

publication date

11 April 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17428920%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

29 December 2019

published in

1 reference

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29 December 2019

volume

104

1 reference

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29 December 2019

page(s)

6511-6518

1 reference

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29 December 2019

issue

16

1 reference

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Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

29 December 2019

cites work

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Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis

7 April 2017

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Structural mechanism for sterol sensing and transport by OSBP-related proteins

7 April 2017

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Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

7 April 2017

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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

7 April 2017

1 reference

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Do oxysterols control cholesterol homeostasis?

7 April 2017

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

7 April 2017

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Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

7 April 2017

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7 April 2017

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Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs

7 April 2017

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

7 April 2017

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SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

7 April 2017

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Oxysterol biosynthetic enzymes

7 April 2017

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

7 April 2017

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

7 April 2017

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

7 April 2017

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Protein sensors for membrane sterols

7 April 2017

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Bi-directional protein transport between the ER and Golgi

7 April 2017

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Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

7 April 2017

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Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

28 September 2017

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The SREBP pathway in Drosophila: regulation by palmitate, not sterols

28 September 2017

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The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols

28 September 2017

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Regulation of gene expression by SREBP and SCAP.

28 September 2017

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Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

28 September 2017

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28 September 2017

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Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

28 September 2017

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28 September 2017

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Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.

30 May 2018

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Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamste

30 May 2018

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30 May 2018

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Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

30 May 2018

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Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

28 November 2018

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28 November 2018

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On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function.

28 November 2018

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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

28 November 2018

1 reference

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Inhibition of Sterol Synthesis in Cultured Mouse Cells by 7α-Hydroxycholesterol, 7β-Hydroxycholesterol, and 7-Ketocholesterol

28 November 2018

1 reference

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Fluorocholesterols, in contrast to hydroxycholesterols, exhibit interfacial properties similar to cholesterol

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17428920

12 December 2020

inferred from PubMed ID database lookup

Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17428920

12 December 2020

inferred from PubMed ID database lookup

Synthesis and biological evaluation of a new series of sterols as potential hypocholesterolemic agents

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17428920

12 December 2020

inferred from PubMed ID database lookup

Expression, purification, and analysis of MOZ and MORF histone acetyltransferases

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0700899104

7 January 2021

inferred from DOI database lookup

Steroid Requirements for Suppression of HMG CoA Reductase Activity in Cultured Human Fibroblasts

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1073/PNAS.0700899104

Identifiers

DOI

10.1073/PNAS.0700899104

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17428920%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

ADS bibcode

2007PNAS..104.6511R

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17428920%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

2 references