Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells (Q24679386)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12897130%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells (English)

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6 November 2019

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GOA release 2020-03-11

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5

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6 November 2019

author name string

Timothy F Burns

1

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6 November 2019

Peiwen Fei

2

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6 November 2019

Kimberly A Scata

3

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6 November 2019

David T Dicker

4

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6 November 2019

publication date

1 August 2003

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Molecular and Cellular Biology

6 November 2019

language of work or name

English

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published in

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6 November 2019

volume

23

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6 November 2019

issue

16

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6 November 2019

page(s)

5556-5571

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12897130%20AND%20SRC:MED&resulttype=core&format=json

The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity

6 November 2019

cites work

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7 April 2017

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The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

7 April 2017

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

7 April 2017

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7 April 2017

Surfing the p53 network

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WAF1, a potential mediator of p53 tumor suppression

7 April 2017

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Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas

7 April 2017

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Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2

7 April 2017

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Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

7 April 2017

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The physical association and phosphorylation of Cdc25C protein phosphatase by Prk

7 April 2017

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Polo-like kinases: a team that plays throughout mitosis

7 April 2017

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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

7 April 2017

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p53 mutations in human cancers

7 April 2017

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Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

7 April 2017

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Microarray analysis of p53 target gene expression patterns in the spleen and thymus in response to ionizing radiation.

7 April 2017

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Polo-like kinases and centrosome regulation

28 September 2017

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Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA.

28 September 2017

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Functional studies on the role of the C-terminal domain of mammalian polo-like kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner

28 September 2017

1 reference

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Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

28 September 2017

1 reference

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Mitotic checkpoints: from yeast to cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

Polo-like kinases: positive regulators of cell division from start to finish.

28 September 2017

1 reference

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Inactivation of p53 in a Human Ovarian Cancer Cell Line Increases the Sensitivity to Paclitaxel by Inducing G2/M Arrest and Apoptosis

28 September 2017

1 reference

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Activated Polo-Like Kinase Plx1 Is Required at Multiple Points during Mitosis in Xenopus laevis

28 September 2017

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Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

28 September 2017

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Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures

28 September 2017

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

28 September 2017

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Significance of non-standard Philadelphia chromosomes in chronic granulocytic leukaemia

28 September 2017

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Chromosomal changes in thyroid tumors. Relation with DNA content, karyotypic features, and clinical data

28 September 2017

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Identification of an early-growth-response gene encoding a novel putative protein kinase

28 September 2017

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p53 function and dysfunction

28 September 2017

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Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents

28 September 2017

1 reference

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Tissue-specific induction of p53 targets in vivo.

28 September 2017

1 reference

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Expression and phosphorylation of fibroblast-growth-factor-inducible kinase (Fnk) during cell-cycle progression

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

Bypass of abnormal MDM2 inhibition of p53-dependent growth suppression

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

In situ hybridization in cancer and normal tissue

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

The mitotic roles of Polo-like kinase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

On the Regulation and Function of Human Polo-like Kinase 1 (PLK1): Effects of Overexpression on Cell Cycle Progression

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166320

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

28 November 2018

1 reference

12 December 2020

Efficient internalization of the polo-box of polo-like kinase 1 fused to an Antennapedia peptide results in inhibition of cancer cell proliferation

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12 December 2020

The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia

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12 December 2020

A p53-dependent mouse spindle checkpoint

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12 December 2020

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

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12 December 2020

Clinical implications of cytogenetic classification in adult acute lymphoblastic leukaemia patients

1 reference

12 December 2020

Impact of the in vitro technique used on the cytogenetic patterns in pleomorphic adenomas

1 reference

12 December 2020

Cytogenetic investigations of 340 thyroid hyperplasias and adenomas revealing correlations between cytogenetic findings and histology

1 reference

12 December 2020

The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs

1 reference

12 December 2020

Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis

1 reference

12 December 2020

BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression

1 reference

12 December 2020

10.1128/MCB.23.16.5556-5571.2003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12897130%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12897130%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

PubMed publication ID

12897130

1 reference