Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant (Q24675998)

6

object named as

K G Chandy

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author name string

H Wulff

1

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M J Miller

2

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W Hansel

3

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S Grissmer

4

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M D Cahalan

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

5 July 2000

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published in

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volume

97

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issue

14

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page(s)

8151-6

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cites work

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A human intermediate conductance calcium-activated potassium channel

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SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, Jurkat

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Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin

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Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1

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Inhibition of T cell proliferation by selective block of Ca(2+)-activated K(+) channels

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The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.97.14.8151

cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.97.14.8151

Single-channel recording of a store-operated Ca2+ channel in Jurkat T lymphocytes

21 January 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.97.14.8151

Enhancement of calcium signaling and proliferation responses in activated human T lymphocytes. Inhibitory effects of K+ channel block by charybdotoxin depend on the T cell activation state

21 January 2018

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12 December 2020

Influence of some novel N-substituted azoles and pyridines on rat hepatic CYP3A activity

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12 December 2020

The action of blocking agents applied to the inner face of Ca(2+)-activated K+ channels from human erythrocytes

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12 December 2020

The antifungal drug clotrimazole

1 reference

12 December 2020

Effect of inhibitor depletion on inhibitory potency: tight binding inhibition of CYP3A by clotrimazole

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12 December 2020

hSK4/hIK1, a calmodulin-binding KCa channel in human T lymphocytes. Roles in proliferation and volume regulation

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12 December 2020

N-trisubstituted methylimidazoles as antifungal agents

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12 December 2020

Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins

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12 December 2020

Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture

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12 December 2020

Identifiers

DOI

10.1073/PNAS.97.14.8151

1 reference

1065291

ADS bibcode

2000PNAS...97.8151W

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1065291

1 reference

1 reference

1 reference