ShK toxin: history, structure and therapeutic applications for autoimmune diseases (Q55120296)

scientific article published in 2018 in WikiJournal of Science

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English	ShK toxin: history, structure and therapeutic applications for autoimmune diseases	scientific article published in 2018 in WikiJournal of Science

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scholarly article

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Journal first Wikipedia-integrated dual publishing

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title

ShK toxin: history, structure and therapeutic applications for autoimmune diseases (English)

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1

mailto:jeff.chang@ntu.edu.sg

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Saumya Bajaj

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2

object named as

Saumya Bajaj

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George Chandy

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3

object named as

K. George Chandy

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reviewed by

Heike Wulff

point in time

6 March 2018

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unknown value

object of statement has role

10 May 2018

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1 June 2018

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language of work or name

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https://en.wikipedia.org/wiki/Stichodactyla_toxin

point in time

9 June 2018

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work available at URL

https://upload.wikimedia.org/wikiversity/en/c/cf/ShK_toxin_history%2C_structure_and_therapeutic_applications_for_autoimmune_diseases.pdf

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published in

WikiJournal of Science

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volume

1

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issue

1

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page(s)

3

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copyright license

Creative Commons Attribution 4.0 International

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copyright status

copyrighted

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peer review URL

https://en.wikiversity.org/wiki/talk:WikiJournal_of_Science/ShK_toxin:_history,_structure_and_therapeutic_applications_for_autoimmune_diseases

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cites work

Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Active Crohn's disease patients show a distinctive expansion of circulating memory CD4+CD45RO+CD28null T cells.

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Microglia Kv1.3 channels contribute to their ability to kill neurons.

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

The signature sequence of voltage-gated potassium channels projects into the external vestibule

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Selective blockade of T lymphocyte K+channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

CD4+CD28- costimulation-independent T cells in multiple sclerosis

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

A helical capping motif in ShK toxin and its role in helix stabilization

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

695 Topical application of KPI-150, a potent inhibitor of Kv1.3 channels on effector memory T cells, demonstrates preclinical efficacy in atopic dermatitis model

1 reference

4 February 2025

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Potassium channel expression and function in microglia: Plasticity and possible species variations

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis – Xenograft model

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Ionisation behaviour and solution properties of the potassium-channel blocker ShK toxin

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Looking over toxin-K(+) channel interactions. Clues from the structural and functional characterization of α-KTx toxin Tc32, a Kv1.3 channel blocker

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

K+ channels and the microglial respiratory burst

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Voltage-gated and Ca(2+)-activated K+ channels in intact human T lymphocytes. Noninvasive measurements of membrane currents, membrane potential, and intracellular calcium

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Niche-specific gene expression in a parasitic nematode; increased expression of immunomodulators in Teladorsagia circumcincta larvae derived from host mucosa.

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Killer Cell Activating Receptors Function as Costimulatory Molecules on CD4+CD28null T Cells Clonally Expanded in Rheumatoid Arthritis

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Major differences between human atopic dermatitis and murine models, as determined by using global transcriptomic profiling

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Differential effects of membrane perturbants on voltage-activated sodium and calcium channels and calcium-dependent potassium channels

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases.

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Peptide blockers of Kv1.3 channels in T cells as therapeutics for autoimmune disease

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Characterization of a potassium channel toxin from the Caribbean sea anemone Stichodactyla helianthus

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

1 reference

4 February 2025

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Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model

1 reference

4 February 2025

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Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation

1 reference

4 February 2025

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1 reference

4 February 2025

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Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking

1 reference

4 February 2025

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Design and synthesis of type-III mimetics of ShK toxin

1 reference

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A toxin homology domain in an astacin-like metalloproteinase of the jellyfish Podocoryne carnea with a dual role in digestion and development

1 reference

4 February 2025

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Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.

1 reference

4 February 2025

https://opencitations.net/index/api/v1/references/10.15347/WJS/2018.003

On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures

1 reference

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Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease

1 reference

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Autocrine-Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries.

1 reference

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A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes

1 reference

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Blockade of Kv1.3 channels ameliorates radiation-induced brain injury

1 reference

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Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia

1 reference

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Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone

1 reference

4 February 2025

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An essential binding surface for ShK toxin interaction with rat brain potassium channels

1 reference

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Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

1 reference

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A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions

1 reference

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Identification of three separate binding sites on SHK toxin, a potent inhibitor of voltage-dependent potassium channels in human T-lymphocytes and rat brain

1 reference

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Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells

1 reference

4 February 2025

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Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin

1 reference

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Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High-Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography

1 reference

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Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

1 reference

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Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin

1 reference

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Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases

1 reference

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Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.

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Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

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The functional network of ion channels in T lymphocytes

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Voltage-gated potassium channels are required for human T lymphocyte activation

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Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept

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Kv1.3 blockers ameliorate allergic contact dermatitis by preferentially suppressing effector memory T cells in a rat model

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10.15347/WJS/2018.003

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ShK toxin: history, structure and therapeutic applications for autoimmune diseases (Q55120296)

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