Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms (Q24674150)

2

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Agathe Valluet

3

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Carole Peyssonnaux

4

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Alain Eychène

Molecular and Cellular Biology

5

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language of work or name

English

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publication date

January 2007

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published in

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volume

27

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page(s)

31-43

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issue

1

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cites work

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Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

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Regulation of Raf through phosphorylation and N terminus-C terminus interaction

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Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

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Active Ras induces heterodimerization of cRaf and BRaf

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Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins

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Negative regulation of the serine/threonine kinase B-Raf by Akt

7 April 2017

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

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Murine Ksr interacts with MEK and inhibits Ras-induced transformation

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Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system

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Regulation and role of Raf-1/B-Raf heterodimerization

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Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

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Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf

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cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

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The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras

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Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

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The structural basis for 14-3-3:phosphopeptide binding specificity

7 April 2017

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The RAF proteins take centre stage

7 April 2017

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Essential role of B-Raf in ERK activation during extraembryonic development

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Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

28 September 2017

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Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels

28 September 2017

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Regulation of Raf-1 by direct feedback phosphorylation.

28 September 2017

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B-RAF is a therapeutic target in melanoma

28 September 2017

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A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.

28 September 2017

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Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

28 September 2017

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Dephosphorylation of Ser-259 regulates Raf-1 membrane association

28 September 2017

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28 September 2017

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Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

28 September 2017

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Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

28 September 2017

1 reference

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Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways

28 September 2017

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Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

28 September 2017

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Genomic organization and nucleotide sequence of the coding region of the chicken c-Rmil(B-raf-1) proto-oncogene

28 September 2017

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The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression.

28 September 2017

1 reference

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B-raf, a new member of the raf family, is activated by DNA rearrangement

28 September 2017

1 reference

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Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

28 September 2017

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A novel oncogene related to c-mil is transduced in chicken neuroretina cells induced to proliferate by infection with an avian lymphomatosis virus

28 September 2017

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Quail neuroretina c-Rmil(B-raf) proto-oncogene cDNAs encode two proteins of 93.5 and 95 kDa resulting from alternative splicing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800654

Expression and activation of B-Raf kinase isoforms in human and murine leukemia cell lines

28 September 2017

1 reference

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Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800654

Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800654

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800654

Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800654

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

28 November 2018

1 reference

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High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800654

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

28 November 2018

1 reference

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Nerve growth factor-stimulated B-Raf catalytic activity is refractory to inhibition by cAMP-dependent protein kinase.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800654

Phosphorylation by PKA of a site unique to B-Raf kinase.

28 November 2018

1 reference

12 December 2020

Involvement of B-Raf in Ras-induced Raf-1 activation

1 reference

12 December 2020

BRAF Mutation in Papillary Thyroid Carcinoma

1 reference

12 December 2020

Suppression of BRAF(V599E) in human melanoma abrogates transformation

1 reference

12 December 2020

Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway

1 reference

12 December 2020

Directing NGF's actions: it's a Rap

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.01265-06

1 reference

5033066

5033066

1 reference

1 reference

1 reference