NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas (Q24646237)

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English	NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas	scientific article

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NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas (English)

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author name string

Ta-Jen Liu

1

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Dimpy Koul

2

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Tiffany LaFortune

3

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Ningyi Tiao

4

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Rui Jun Shen

5

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Sauveur-Michel Maira

6

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Carlos Garcia-Echevrria

7

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W K Alfred Yung

8

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publication date

August 2009

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Molecular Cancer Therapeutics

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8

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2204-10

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8

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The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

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7 April 2017

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

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Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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7 April 2017

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

1 reference

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7 April 2017

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures

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Autophagy and cell death.

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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

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EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms

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The role of autophagy in cancer development and response to therapy.

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Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.

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27 September 2017

Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.

1 reference

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27 September 2017

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

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27 September 2017

Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis

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27 September 2017

Tumor angiogenesis in stage IB cervical cancer: correlation of microvessel density with survival

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Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines

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Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

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PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment

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30 May 2018

Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.

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30 May 2018

Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy.

1 reference

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28 November 2018

PIK3CA gene mutations in pediatric and adult glioblastoma multiforme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752877

28 November 2018

MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer

1 reference

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28 November 2018

The relevance of cell proliferation, vascular endothelial growth factor, and basic fibroblast growth factor production to angiogenesis and tumorigenicity in human glioma cell lines

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An implantable guide-screw system for brain tumor studies in small animals.

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28 November 2018

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19671762

12 December 2020

based on heuristic

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Autophagy and cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19671762

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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