Dual Inhibitor AEE788 Reduces Tumor Growth in Preclinical Models of Medulloblastoma (Q24615472)

5

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Riccardo Riccardi

7

object named as

Riccardo Riccardi

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Daniela Meco

object named as

Daniela Meco

1

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author name string

Tiziana Servidei

2

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Enrica Martinelli

4

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Chiara de Waure

6

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language of work or name

English

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publication date

2010

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published in

Translational Oncology

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Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941

Crossref

volume

3

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page(s)

326-35

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issue

5

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cites work

1 reference

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A perivascular niche for brain tumor stem cells

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Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

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HER3 comes of age: new insights into its functions and role in signaling, tumor biology, and cancer therapy

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AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer

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Targeting vascular endothelial growth factor receptor in thyroid cancer: the intracellular and extracellular implications

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Kinome profiling in pediatric brain tumors as a new approach for target discovery

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Antitumor effect in medulloblastoma cells by gefitinib: Ectopic HER2 overexpression enhances gefitinib effects in vivo

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Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib

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Autocrine regulation of glioblastoma cell cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay

27 September 2017

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A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy

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Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications

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Functional VEGF and VEGF receptors are expressed in human medulloblastomas

27 September 2017

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Angiogenesis in brain tumours

27 September 2017

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Dual epidermal growth factor receptor and vascular endothelial growth factor receptor inhibition with NVP-AEE788 for the treatment of aggressive follicular thyroid cancer

27 September 2017

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ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells

27 September 2017

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Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition.

27 September 2017

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AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity

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Medulloblastoma: signalling a change in treatment

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Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology

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Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model

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https://pubmed.ncbi.nlm.nih.gov/20885895