Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems (Q24597270)

Europe PubMed Central

title

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems (English)

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1 reference

2

James C Whisstock

James C

Whisstock

1 reference

1 January 2024

Phillip I Bird

9

Phillip I

Bird

1 reference

1 January 2024

3

Stephen P Bottomley

Stephen P

Bottomley

1 reference

1 January 2024

Gary A Silverman

1

Gary A

Silverman

1 reference

1 January 2024

James A Huntington

4

James A

Huntington

1 reference

1 January 2024

Dion Kaiserman

5

Dion

Kaiserman

1 reference

1 January 2024

Cliff J Luke

6

Cliff J

Luke

1 reference

1 January 2024

Stephen C Pak

7

Stephen C

Pak

1 reference

1 January 2024

Jean-Marc Reichhart

8

Jean-Marc

Reichhart

1 reference

Journal of Biological Chemistry

1 January 2024

language of work or name

English

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publication date

6 August 2010

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published in

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volume

285

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issue

32

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page(s)

24299-305

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cites work

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions

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Arabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21)

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Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes

24 March 2017

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Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1

24 March 2017

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A serpin that regulates immune melanization in the respiratory system of Drosophila

24 March 2017

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An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury

24 March 2017

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X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

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24 March 2017

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Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke

24 March 2017

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SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases

24 March 2017

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Male fertility defects in mice lacking the serine protease inhibitor protease nexin-1

24 March 2017

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Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis

24 March 2017

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Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin

24 March 2017

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Maspin plays an essential role in early embryonic development

24 March 2017

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The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency

24 March 2017

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Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development

24 March 2017

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Disruption of the murine alpha1-antitrypsin/PI2 gene

24 March 2017

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The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

24 March 2017

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Control of granzymes by serpins.

7 April 2017

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Three pairs of protease-serpin complexes cooperatively regulate the insect innate immune responses

27 September 2017

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A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

27 September 2017

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Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia

27 September 2017

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Exosite determinants of serpin specificity

27 September 2017

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The role of plasminogen activator inhibitor 1 in renal and cardiovascular diseases.

27 September 2017

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The plasminogen activator system and cancer

27 September 2017

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Drosophila toll pathway: the new model

27 September 2017

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The multi-functional serpin, protein C inhibitor: beyond thrombosis and hemostasis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915665

Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915665

Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll

27 September 2017

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Serpins in plants and green algae

27 September 2017

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SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change

27 September 2017

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Molecular gymnastics: serpin structure, folding and misfolding

27 September 2017

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Serpin1 of Arabidopsis thaliana is a suicide inhibitor for metacaspase 9.

27 September 2017

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The Spn4 gene from Drosophila melanogaster is a multipurpose defence tool directed against proteases from three different peptidase families

27 September 2017

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Shape-shifting serpins--advantages of a mobile mechanism

27 September 2017

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Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915665

The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915665

Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic

27 September 2017

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Tip of another iceberg: Drosophila serpins

27 September 2017

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Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915665

SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins

27 September 2017

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Spatial regulation of developmental signaling by a serpin

27 September 2017

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A serpin regulates dorsal-ventral axis formation in the Drosophila embryo.

27 September 2017

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A serpin mutant links Toll activation to melanization in the host defence of Drosophila

27 September 2017

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Drosophila innate immunity: an evolutionary perspective

27 September 2017

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Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

27 September 2017

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Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins.

27 September 2017

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MENT, a heterochromatin protein that mediates higher order chromatin folding, is a new serpin family member

27 September 2017

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A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9).

27 September 2017

1 reference

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Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis

27 September 2017

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Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization

27 September 2017

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PEDF-deficient mice exhibit an enhanced rate of retinal vascular expansion and are more sensitive to hyperoxia-mediated vessel obliteration

27 September 2017

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An immune-responsive Serpin regulates the melanization cascade in Drosophila

30 May 2018

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Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response.

21 January 2018

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Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.R110.112771

An Inhibitor of Serine Proteases, Neuroserpin, Acts as a Neuroprotective Agent in a Mouse Model of Neurodegenerative Disease

21 January 2018

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Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice

21 January 2018

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Functional diversification of a protease inhibitor gene in the genus Drosophila and its molecular basis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.R110.112771

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.R110.112771

Activation of Drosophila Toll during fungal infection by a blood serine protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.112771

Comparison of Human Chromosome 6p25 with Mouse Chromosome 13 Reveals a Greatly Expanded Ov-Serpin Gene Repertoire in the Mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.112771

Absence of mutations in the PCI gene in subfertile men

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20498369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.R110.112771

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Fatcat ID

release_7eoitaoonvd3pmklaxhm5xohka

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PMC publication ID

2915665

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