Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression (Q24595357)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778339%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression (English)

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8 February 2020

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5

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8 February 2020

author name string

Marcela Franco

1

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8 February 2020

Pernilla Roswall

2

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8 February 2020

Eliane Cortez

3

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8 February 2020

Douglas Hanahan

4

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8 February 2020

language of work or name

English

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publication date

21 July 2011

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8 February 2020

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8 February 2020

volume

118

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8 February 2020

issue

10

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8 February 2020

page(s)

2906-2917

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

8 February 2020

cites work

1 reference

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Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

24 March 2017

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Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

24 March 2017

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Sorafenib in advanced clear-cell renal-cell carcinoma

24 March 2017

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Sunitinib versus interferon alfa in metastatic renal-cell carcinoma

24 March 2017

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NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival

24 March 2017

1 reference

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24 March 2017

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Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

7 April 2017

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Endothelial/pericyte interactions

7 April 2017

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VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

7 April 2017

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Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.

7 April 2017

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Hallmarks of cancer: interactions with the tumor stroma.

27 September 2017

1 reference

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Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation

27 September 2017

1 reference

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Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy.

27 September 2017

1 reference

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Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors

27 September 2017

1 reference

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Impact of vessel maturation on antiangiogenic therapy in ovarian cancer

27 September 2017

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Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial

27 September 2017

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Autocrine VEGF signaling is required for vascular homeostasis

27 September 2017

1 reference

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Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102

27 September 2017

1 reference

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Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content

27 September 2017

1 reference

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NF-kappaB regulation of endothelial cell function during LPS-induced toxemia and cancer

27 September 2017

1 reference

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Insight into the physiological functions of PDGF through genetic studies in mice

27 September 2017

1 reference

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Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172806

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172806

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172806

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

27 September 2017

1 reference

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Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors

27 September 2017

1 reference

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Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

27 September 2017

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Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

27 September 2017

1 reference

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Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells

27 September 2017

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A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF.

30 May 2018

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The absence of pericytes does not increase the sensitivity of tumor vasculature to vascular endothelial growth factor-A blockade

30 May 2018

1 reference

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Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451.

28 November 2018

1 reference

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A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer.

28 November 2018

1 reference

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Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms

28 November 2018

1 reference

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Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival

28 November 2018

1 reference

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Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury

28 November 2018

1 reference

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Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172806

Deprived of habitual running, rats downregulate BDNF and TrkB messages in the brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172806

Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172806

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172806

Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells

28 November 2018

1 reference

12 December 2020

Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells

1 reference

12 December 2020

Antiangiogenesis is produced by nontoxic doses of vinblastine

1 reference

12 December 2020

Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism

1 reference

12 December 2020

Vitronectin decreases microvascular endothelial cell apoptosis

1 reference

12 December 2020

10.1182/BLOOD-2011-01-331694

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778339%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778339%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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