The growth hormone secretagogue receptor: its intracellular signaling and regulation (Q24568026)

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11 March 2020

review article

2 references

26 August 2020

The growth hormone secretagogue receptor: its intracellular signaling and regulation (English)

1 reference

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11 March 2020

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cell surface receptor

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31 July 2019

physiological phenomenon

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15 December 2019

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26 August 2020

3

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11 March 2020

author name string

Yue Yin

series ordinal

1

1 reference

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11 March 2020

Yin Li

series ordinal

2

1 reference

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11 March 2020

language of work or name

English

0 references

publication date

19 March 2014

7 references

31 July 2019

20 August 2019

17 November 2019

20 November 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24651458%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

26 August 2020

International Journal of Molecular Sciences

7 references

31 July 2019

20 August 2019

17 November 2019

20 November 2019

15 December 2019

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11 March 2020

26 August 2020

15

1 reference

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11 March 2020

issue

3

1 reference

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11 March 2020

page(s)

4837-4855

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Creative Commons Attribution 3.0 Unported

11 March 2020

copyright license

6 references

31 July 2019

20 August 2019

17 November 2019

20 November 2019

15 December 2019

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

26 August 2020

0 references

1 reference

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1 reference

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Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects

24 March 2017

1 reference

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1 reference

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24 March 2017

1 reference

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A receptor in pituitary and hypothalamus that functions in growth hormone release

24 March 2017

1 reference

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Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.

24 March 2017

1 reference

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Common structural basis for constitutive activity of the ghrelin receptor family

24 March 2017

1 reference

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High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist

24 March 2017

1 reference

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Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

24 March 2017

1 reference

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Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion

24 March 2017

1 reference

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Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors

24 March 2017

1 reference

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mTOR signaling at a glance

24 March 2017

1 reference

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Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling

7 April 2017

1 reference

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Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling

27 September 2017

1 reference

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Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin

27 September 2017

1 reference

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Ghrelin induces cardiac lineage differentiation of human embryonic stem cells through ERK1/2 pathway.

27 September 2017

1 reference

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Growth hormone secretagogue receptor (GHS-R1a) knockout mice exhibit improved spatial memory and deficits in contextual memory

27 September 2017

1 reference

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Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism

27 September 2017

1 reference

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Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors

27 September 2017

1 reference

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Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1/2 and PI3K/Akt pathways

27 September 2017

1 reference

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In vivo characterization of high Basal signaling from the ghrelin receptor

27 September 2017

1 reference

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Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor

27 September 2017

1 reference

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Adenosine is not a direct GHSR agonist--artificial cross-talk between GHSR and adenosine receptor pathways.

27 September 2017

1 reference

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Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C.

27 September 2017

1 reference

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Biological, physiological, and pharmacological aspects of ghrelin

27 September 2017

1 reference

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Molecular mechanism of 7TM receptor activation--a global toggle switch model

27 September 2017

1 reference

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Developments in ghrelin biology and potential clinical relevance

27 September 2017

1 reference

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Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study.

27 September 2017

1 reference

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The AMP-activated protein kinase pathway--new players upstream and downstream.

27 September 2017

1 reference

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Agonist-specific coupling of growth hormone secretagogue receptor type 1a to different intracellular signaling systems. Role of adenosine

27 September 2017

1 reference

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Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature

27 September 2017

1 reference

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Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a.

27 September 2017

1 reference

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Structure and regulation of the growth hormone secretagogue receptor

27 September 2017

1 reference

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Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells.

27 September 2017

1 reference

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Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding (CREB) phosphorylation and nuclear CREB: the involvement of protein kinases A and C.

27 September 2017

1 reference

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Hormonal regulation of the human ghrelin receptor gene transcription

27 September 2017

1 reference

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Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor

27 September 2017

1 reference

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Thyroid hormones regulate pituitary growth hormone secretagogue receptor gene expression

27 September 2017

1 reference

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In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat.

27 September 2017

1 reference

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High plasma growth hormone (GH) levels inhibit expression of GH secretagogue receptor messenger ribonucleic acid levels in the rat pituitary

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans

27 September 2017

1 reference

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Cloning and characterization of the 5'-flanking region of the human growth hormone secretagogue receptor gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Peptidomimetic regulation of growth hormone secretion

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Ghrelin is neuroprotective in Parkinson's disease: molecular mechanisms of metabolic neuroprotection

27 September 2017

1 reference

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Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop

27 September 2017

1 reference

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Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers.

30 May 2018

1 reference

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The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes

30 May 2018

1 reference

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Developmentally and regionally regulated expression of growth hormone secretagogue receptor mRNA in rat brain and pituitary gland.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Growth hormone (GH)-releasing hormone (GHRH) and the GH secretagogue (GHS), L692,585, differentially modulate rat pituitary GHS receptor and GHRH receptor messenger ribonucleic acid levels

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Structural requirements for the activation of the human growth hormone secretagogue receptor by peptide and nonpeptide secretagogues

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Regulation of the pituitary-specific transcription factor GHF-1/Pit-1 messenger ribonucleic acid levels by growth hormone-secretagogues in rat anterior pituitary cells in monolayer culture

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3',5'-monophosphate accumulation in rat primary pituitary cell culture

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Two types of voltage-dependent calcium current in rat somatotrophs are reduced by somatostatin.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Evidence for a Role of Protein Kinase-C in His-D-Trp Ala-Trp-D-Phe-Lys-NH2-Induced Growth Hormone Release from Rat Primary Pituitary Cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Growth hormone-releasing peptide (GHRP).

30 May 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Construction of human ghrelin receptor (hGHS-R1a) model using a fragmental prediction approach and validation through docking analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Novel inactivating mutations in the GH secretagogue receptor gene in patients with constitutional delay of growth and puberty.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Ghrelin contributes to protection of hepatocellular injury induced by ischaemia/reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH, pituitary transcription factor-1, GHRH-receptor, GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Homologous and heterologous regulation of pituitary receptors for ghrelin and growth hormone-releasing hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

The truncated ghrelin receptor polypeptide (GHS-R1b) is localized in the endoplasmic reticulum where it forms heterodimers with ghrelin receptors (GHS-R1a) to attenuate their cell surface expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Activation of the ghrelin receptor is described by a privileged collective motion: a model for constitutive and agonist-induced activation of a sub-class A G-protein coupled receptor (GPCR).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Impaired wake-promoting mechanisms in ghrelin receptor-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Peptidomimetic Regulation of Growth Hormone Secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

Ghrelin inhibits apoptosis induced by palmitate in rat aortic endothelial cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975427

Ghrelin protects heart against ERS-induced injury and apoptosis by activating AMP-activated protein kinase

28 November 2018

1 reference

12 December 2020

Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor

1 reference

12 December 2020

The growth hormone secretagogue, L-692,429, induces phosphatidylinositol hydrolysis and hormone secretion by human pituitary tumors

1 reference

12 December 2020

Mutational analysis of predicted extracellular domains of human growth hormone secretagogue receptor 1a

1 reference

12 December 2020

Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells

1 reference

12 December 2020

Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1

1 reference

12 December 2020

Growth Hormone (GH)-Releasing Hormone (GHRH) and the GH Secretagogue (GHS), L692,585, Differentially Modulate Rat Pituitary GHS Receptor and GHRH Receptor Messenger Ribonucleic Acid Levels1

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15034837

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.3390/IJMS15034837

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24651458%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24651458%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24651458%20AND%20SRC:MED&resulttype=core&format=json