Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects (Q24302568)

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English	Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects	scientific article

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scholarly article

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Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects (English)

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apoptotic process

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Ghrelin and obestatin prepropeptide

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GOA release 2020-03-11

protein tyrosine kinase activator activity

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GOA release 2020-03-11

Ludwik Malendowicz

6

object named as

Ludwik K Malendowicz

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Marcin Rucinski

3

object named as

Marcin Rucinski

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author name string

Giuseppina Mazzocchi

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Giuliano Neri

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Piera Rebuffat

4

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Raffaella Spinazzi

5

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Gastone G Nussdorfer

7

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language of work or name

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publication date

August 2004

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25

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8

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1269-77

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Tyrosine kinase-independent inhibition of cyclic-AMP phosphodiesterase by genistein and tyrphostin 51.

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Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland

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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

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Tyrphostins as molecular tools and potential antiproliferative drugs

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Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness

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Ghrelin in fetal thyroid and follicular tumors and cell lines: expression and effects on tumor growth

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Endothelin-1[1-31], acting as an ETA-receptor selective agonist, stimulates proliferation of cultured rat zona glomerulosa cells

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Ghrelin and growth hormone secretagogue receptor are expressed in the rat adrenal cortex: Evidence that ghrelin stimulates the growth, but not the secretory activity of adrenal cells

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Ghrelin, a widespread hormone: insights into molecular and cellular regulation of its expression and mechanism of action.

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Proadrenomedullin-derived peptides in the paracrine control of the hypothalamo-pituitary-adrenal axis

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Proadrenomedullin N-terminal 20 peptide (PAMP) enhances proliferation of rat zona glomerulosa cells by activating MAPK cascade

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The p38 signal transduction pathway: activation and function

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Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor

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Ghrelin is a growth-hormone-releasing acylated peptide from stomach

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Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function

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Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells

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Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.

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11beta-hydroxysteroid dehydrogenase expression and activity in the human adrenal cortex

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Adrenomedullin stimulates DNA synthesis of rat adrenal zona glomerulosa cells through activation of the mitogen-activated protein kinase-dependent cascade.

1 reference

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A receptor in pituitary and hypothalamus that functions in growth hormone release

1 reference

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based on heuristic

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Endocrine and non-endocrine actions of ghrelin.

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The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation

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Ghrelin-induced food intake is mediated via the orexin pathway

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Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors.

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Cholecystokinin (CCK) stimulates aldosterone secretion from human adrenocortical cells via CCK2 receptors coupled to the adenylate cyclase/protein kinase A signaling cascade

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Pituitary adenylate-cyclase activating peptide enhances aldosterone secretion of human adrenal gland: evidence for an indirect mechanism, probably involving the local release of catecholamines

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Effects of adrenomedullin on the human adrenal glands: an in vitro study

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Cerebellin enhances in vitro secretory activity of human adrenal gland

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Identification, Characterization, and Biological Activity of Specific Receptors for Natural (Ghrelin) and Synthetic Growth Hormone Secretagogues and Analogs in Human Breast Carcinomas and Cell Lines

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Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growth

1 reference

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Biologic activities of growth hormone secretagogues in humans

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Presence of ghrelin in normal and adenomatous human pituitary.

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Hexarelin protects H9c2 cardiomyocytes from doxorubicin-induced cell death.

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Expression and homologous regulation of GH secretagogue receptor mRNA in rat adrenal gland

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Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines

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Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines

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Natural (ghrelin) and synthetic (hexarelin) GH secretagogues stimulate H9c2 cardiomyocyte cell proliferation.

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10.1016/J.PEPTIDES.2004.05.011

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