A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28 (Q24339085)

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English	A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28	scientific article

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A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28 (English)

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Takashi Saito

5

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author name string

Kok-Fai Kong

1

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Tadashi Yokosuka

2

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Ann J Canonigo-Balancio

3

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Noah Isakov

4

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Amnon Altman

6

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publication date

November 2011

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Nature Immunology

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12

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1105-12

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11

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CD28 and CTLA-4 coreceptor expression and signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

19 March 2017

Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

19 March 2017

Three-dimensional segregation of supramolecular activation clusters in T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

19 March 2017

Selective modulation of protein kinase C-theta during T-cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

19 March 2017

Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

19 March 2017

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

19 March 2017

Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

19 March 2017

Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

19 March 2017

The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

7 April 2017

https://api.crossref.org/works/10.1038%2FNI.2120

7 January 2021

based on heuristic

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Understanding the structure and function of the immunological synapse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Small molecule inhibitors of PKCTheta as potential antiinflammatory therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

The cellular context of T cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Two pathways of costimulation through CD28.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Signals and sequences that control CD28 localization to the central region of the immunological synapse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Protein kinase C theta (PKCtheta): a key player in T cell life and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

C1 domains exposed: from diacylglycerol binding to protein-protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Protein kinase C theta is not essential for T-cell-mediated clearance of murine gammaherpesvirus 68.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

PKCtheta signals activation versus tolerance in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

CD28-mediated co-stimulation: a quantitative support for TCR signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

27 September 2017

Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

30 May 2018

Multiple modes of interaction between Lck and CD28.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

30 May 2018

A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

30 May 2018

Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197934

30 May 2018

Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNI.2120

21 January 2018

Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis.

1 reference

https://api.crossref.org/works/10.1038%2FNI.2120

21 January 2018

Ca2+ differentially regulates conventional protein kinase Cs' membrane interaction and activation

1 reference

https://api.crossref.org/works/10.1038%2FNI.2120

21 January 2018

Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta.

1 reference

https://api.crossref.org/works/10.1038%2FNI.2120

21 January 2018

Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation

1 reference

https://api.crossref.org/works/10.1038%2FNI.2120

21 January 2018

Generation of T-cell receptor retrogenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNI.2120

21 January 2018

Diacylglycerol and Protein Kinase D Localization during T Lymphocyte Activation

1 reference

https://api.crossref.org/works/10.1038%2FNI.2120

21 January 2018

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI.2120

21 January 2018

Involvement of p21ras activation in T cell CD69 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCR antagonist peptides induce formation of APC-T cell conjugates and activate a Rac signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21964608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/NI.2120

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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10.1038/ni.2120

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