14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage (Q24338975)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Hidemasa Goto

2

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Masaki Inagaki

6

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Tohru Kiyono

5

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author name string

Kousuke Kasahara

1

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Masato Enomoto

3

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Yasuko Tomono

NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

4

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language of work or name

English

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publication date

18 August 2010

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published in

The EMBO Journal

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volume

29

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issue

16

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page(s)

2802-12

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cites work

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Crystal structure of the zeta isoform of the 14-3-3 protein

19 March 2017

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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

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Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345

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Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation

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C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding

19 March 2017

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

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Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation

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Rapid destruction of human Cdc25A in response to DNA damage

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Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.

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CDC25A levels determine the balance of proliferation and checkpoint response

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Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit

27 September 2017

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Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

27 September 2017

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Lack of PTEN sequesters CHK1 and initiates genetic instability.

27 September 2017

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Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

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Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

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27 September 2017

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Production of a site- and phosphorylation state-specific antibody.

27 September 2017

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Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function

30 May 2018

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14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.

21 January 2018

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Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

21 January 2018

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Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation

21 January 2018

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Checkpoint on the nuclear frontier

21 January 2018

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Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice.

21 January 2018

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CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage.

21 January 2018

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Checkpoints on the road to mitosis

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