Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol (Q24337975)

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English	Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol	scientific article

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scholarly article

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Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol (English)

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Nuclear receptor subfamily 1 group H member 2

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GOA release 2020-03-11

Lanosterol synthase

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GOA release 2020-03-11

Nuclear receptor subfamily 1 group H member 3

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GOA release 2020-03-11

positive regulation of lipoprotein lipase activity

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GOA release 2020-03-11

Robert A. Hegele

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object named as

Robert A Hegele

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Janet G Markle

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Murray W Huff

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author name string

Michael M Beyea

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Claire L Heslop

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Cynthia G Sawyez

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Jane Y Edwards

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language of work or name

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publication date

23 February 2007

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Journal of Biological Chemistry

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282

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8

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5207-16

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Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Liver X Receptor Signaling Pathways in Cardiovascular Disease

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Uptake of type III hypertriglyceridemic VLDL by macrophages is enhanced by oxidation, especially after remnant formation

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Activation of peroxisome proliferator-activated receptor gamma and retinoid X receptor results in net depletion of cellular cholesteryl esters in macrophages exposed to oxidized lipoproteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Retinoid x receptor heterodimers in the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Role of LXRs in control of lipogenesis

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

21 January 2018

Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611063200

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo

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https://api.crossref.org/works/10.1074%2FJBC.M611063200

7 January 2021

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inferred from DOI database lookup

Identifiers

10.1074/JBC.M611063200

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Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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