The kinase TNIK is an essential activator of Wnt target genes (Q24323107)

GOA release 2020-03-11

author

Hans Clevers

8

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Shabaz Mohammed

object named as

Shabaz Mohammed

6

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Albert J.R. Heck

object named as

Albert J Heck

7

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Tokameh Mahmoudi

1

object named as

Tokameh Mahmoudi

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author name string

Vivian S W Li

2

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Ser Sue Ng

3

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Nadia Taouatas

4

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Robert G J Vries

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

5

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language of work or name

English

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publication date

4 November 2009

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published in

The EMBO Journal

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volume

28

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issue

21

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page(s)

3329-40

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cites work

1 reference

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The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation

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TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

19 March 2017

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

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The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors

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Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.285

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.285

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2009.285

1 reference

1 reference

1 reference

PubMed publication ID

19816403

1 reference