Early nonsense: mRNA decay solves a translational problem (Q36488710)

14 August 2017

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title

Early nonsense: mRNA decay solves a translational problem (English)

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14 August 2017

Matthew S Sachs

2

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author name string

Nadia Amrani

series ordinal

1

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PubMed ID

16723977

14 August 2017

Allan Jacobson

series ordinal

3

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14 August 2017

1 June 2006

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Nature Reviews Molecular Cell Biology

14 August 2017

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14 August 2017

7

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14 August 2017

415-425

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14 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrm1942

14 August 2017

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31 March 2020

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31 March 2020

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The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

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31 March 2020

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31 March 2020

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Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen

31 March 2020

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Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p

31 March 2020

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Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae

31 March 2020

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The case against the involvement of the NMD proteins in programmed frameshifting

31 March 2020

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Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

31 March 2020

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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

31 March 2020

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The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts

31 March 2020

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Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay

31 March 2020

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Linking mRNA turnover and translation: assessing the polyribosomal association of mRNA decay factors and degradative intermediates.

31 March 2020

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Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA.

31 March 2020

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Nonsense suppressors partially revert the decrease of the mRNA level of a nonsense mutant allele in yeast

31 March 2020

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Interference of nonsense mutations with eukaryotic messenger RNA stability

31 March 2020

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Ribosome occupancy of the yeast CPA1 upstream open reading frame termination codon modulates nonsense-mediated mRNA decay

31 March 2020

1 reference

Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans

31 March 2020

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Regulation of mRNA translation by 5'- and 3'-UTR-binding factors

31 March 2020

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Regulation of cap-dependent translation by eIF4E inhibitory proteins

31 March 2020

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AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors

31 March 2020

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The search for trans-acting factors controlling messenger RNA decay.

31 March 2020

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Formation of the 3' end of histone mRNA

31 March 2020

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Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution

31 March 2020

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mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?

31 March 2020

1 reference

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor

31 March 2020

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A 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus

31 March 2020

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The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames

31 March 2020

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mRNA surveillance in mammalian cells: the relationship between introns and translation termination

31 March 2020

1 reference

The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay

31 March 2020

1 reference

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

31 March 2020

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The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

31 March 2020

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eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay

31 March 2020

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The ever-increasing complexities of the exon junction complex

31 March 2020

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Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes

31 March 2020

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Translation of aberrant mRNAs lacking a termination codon or with a shortened 3'-UTR is repressed after initiation in yeast

31 March 2020

1 reference

Translation termination factor eRF3 mediates mRNA decay through the regulation of deadenylation.

31 March 2020

1 reference

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay

31 March 2020

1 reference

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay

31 March 2020

1 reference

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

31 March 2020

1 reference

A perfect message: RNA surveillance and nonsense-mediated decay

31 March 2020

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RNA splicing promotes translation and RNA surveillance

31 March 2020

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The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

31 March 2020

1 reference

Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

31 March 2020

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A new function for nonsense-mediated mRNA-decay factors

31 March 2020

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Exon junction complexes mediate the enhancing effect of splicing on mRNA expression

31 March 2020

1 reference

Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

31 March 2020

1 reference

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

31 March 2020

1 reference

An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay

31 March 2020

1 reference

The protein Mago provides a link between splicing and mRNA localization.

31 March 2020

1 reference

Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1

31 March 2020

1 reference

Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay

31 March 2020

1 reference

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.

31 March 2020

1 reference

Inhibition of translation termination mediated by an interaction of eukaryotic release factor 1 with a nascent peptidyl-tRNA.

31 March 2020

1 reference

Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination

31 March 2020

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A newly discovered function for RNase L in regulating translation termination

31 March 2020

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Driving change: the evolution of alternative genetic codes.

31 March 2020

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Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes

31 March 2020

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SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans

31 March 2020

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Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

31 March 2020

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Selection of the initiator tRNA by Escherichia coli initiation factors.

31 March 2020

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Conversion of 48S translation preinitiation complexes into 80S initiation complexes as revealed by toeprinting.

31 March 2020

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Primer extension analysis of eukaryotic ribosome-mRNA complexes

31 March 2020

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Toeprint analysis of the positioning of translation apparatus components at initiation and termination codons of fungal mRNAs

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1942

1 reference

14 August 2017

1 reference

PubMed ID

16723977