Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme (Q24321455)

GOA release 2020-03-11

snRNA modification

1 reference

GOA release 2020-03-11

author

Jack Greenblatt

10

0 references

Mathieu Blanchette

14

0 references

Qintong Li

Qintong Li

4

0 references

David H Price

David H Price

15

0 references

Benoit Coulombe

16

Benoit Coulombe

0 references

Célia Jeronimo

1

Célia Jeronimo

0 references

Christian Poitras

6

Christian Poitras

0 references

Annie Bouchard

3

Annie Bouchard

0 references

Diane Forget

2

Diane Forget

0 references

Cynthia Thérien

7

Cynthia Thérien

0 references

author name string

Gordon Chua

5

0 references

Dominique Bergeron

8

0 references

Sylvie Bourassa

9

0 references

Benoit Chabot

11

0 references

Guy G Poirier

12

0 references

Timothy R Hughes

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb

13

0 references

language of work or name

English

0 references

publication date

20 July 2007

0 references

published in

Molecular Cell

0 references

volume

27

0 references

page(s)

262-74

0 references

issue

2

0 references

cites work

1 reference

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Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II

19 March 2017

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UXT is a novel centrosomal protein essential for cell viability

19 March 2017

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

19 March 2017

1 reference

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HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK

19 March 2017

1 reference

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Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription

19 March 2017

1 reference

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Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling

19 March 2017

1 reference

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Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

19 March 2017

1 reference

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A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb

19 March 2017

1 reference

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Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

19 March 2017

1 reference

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MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

19 March 2017

1 reference

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p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor

19 March 2017

1 reference

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A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA

19 March 2017

1 reference

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Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

19 March 2017

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A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro

19 March 2017

1 reference

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TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a

19 March 2017

1 reference

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Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin

19 March 2017

1 reference

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Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function

19 March 2017

1 reference

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Three-dimensional structure of the armadillo repeat region of beta-catenin

19 March 2017

1 reference

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A generic protein purification method for protein complex characterization and proteome exploration

19 March 2017

1 reference

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RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits

19 March 2017

1 reference

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Exploration of essential gene functions via titratable promoter alleles

19 March 2017

1 reference

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High-definition macromolecular composition of yeast RNA-processing complexes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Mechanisms of alternative pre-messenger RNA splicing

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Controlling the elongation phase of transcription with P-TEFb

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Biogenesis of small nuclear RNPs

19 March 2017

1 reference

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Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Comprehensive proteomic analysis of the human spliceosome

19 March 2017

1 reference

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HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110

19 March 2017

1 reference

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The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients

19 March 2017

1 reference

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The WD repeat: a common architecture for diverse functions

19 March 2017

1 reference

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Integrating mRNA processing with transcription

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Pre-mRNA splicing: awash in a sea of proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Histone and chromatin cross-talk

7 April 2017

1 reference

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RNA polymerase II and the integration of nuclear events

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Molecular genetics of the RNA polymerase II general transcriptional machinery

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

A Mediator-responsive form of metazoan RNA polymerase II.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Cotranscriptional mRNP assembly: from the DNA to the nuclear pore

27 September 2017

1 reference

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ATP-dependent chromatin remodeling

27 September 2017

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Tetratricopeptide repeat cochaperones in steroid receptor complexes

27 September 2017

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27 September 2017

1 reference

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Cell signalling and the control of pre-mRNA splicing.

27 September 2017

1 reference

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Structure and mechanism of the RNA polymerase II transcription machinery

27 September 2017

1 reference

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Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation

27 September 2017

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MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters.

27 September 2017

1 reference

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27 September 2017

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DNA bending and wrapping around RNA polymerase: a "revolutionary" model describing transcriptional mechanisms.

27 September 2017

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Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase.

27 September 2017

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Intracellular distribution of low molecular weight RNA species in HeLa cells

27 September 2017

1 reference

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Characterization of U6 small nuclear RNA cap-specific antibodies. Identification of gamma-monomethyl-GTP cap structure in 7SK and several other human small RNAs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

B2 RNA and 7SK RNA, RNA polymerase III transcripts, have a cap-like structure at their 5′ end

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Characterization of antibodies against methyl-pppN cap structure: plant U3 small nucleolar RNA is recognized by these antibodies

27 September 2017

1 reference

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Methylated cap structures in eukaryotic RNAs: structure, synthesis and functions

27 September 2017

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Enzyme cleaving the 5′-terminal methylated blocked structure of messenger RNA

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498903

Sequential Peptide Affinity (SPA) system for the identification of mammalian and bacterial protein complexes.

29 November 2018

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Identification of drosophila bicoid-interacting proteins using a custom two-hybrid selection.

29 November 2018

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Cap structure of U3 small nucleolar RNA in animal and plant cells is different. gamma-Monomethyl phosphate cap structure in plant RNA

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17643375

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17643375

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2007.06.027

1 reference

3961755

3961755

1 reference

1 reference

1 reference