HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells. (Q35829330)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17395637%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

title

HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells (English)

1 reference

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28 December 2019

1 reference

1

1 reference

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28 December 2019

Madeline Shea

5

1 reference

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28 December 2019

David H Price

6

1 reference

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28 December 2019

author name string

Jeffrey J Cooper

2

1 reference

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28 December 2019

Gary H Altwerger

3

1 reference

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28 December 2019

Michael D Feldkamp

4

1 reference

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28 December 2019

language of work or name

English

0 references

publication date

29 March 2007

1 reference

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28 December 2019

published in

Nucleic Acids Research

1 reference

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28 December 2019

volume

35

1 reference

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28 December 2019

issue

8

1 reference

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28 December 2019

page(s)

2503-2512

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17395637%20AND%20SRC:MED&resulttype=core&format=json

The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation

28 December 2019

cites work

1 reference

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Controlling the elongation phase of transcription with P-TEFb

11 July 2018

1 reference

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Mechanisms controlling CDK9 activity

11 July 2018

1 reference

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Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM1 binding

11 July 2018

1 reference

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Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb

11 July 2018

1 reference

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Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

11 July 2018

1 reference

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

11 July 2018

1 reference

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Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer

11 July 2018

1 reference

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Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

The double-stranded RNA-binding motif, a versatile macromolecular docking platform

11 July 2018

1 reference

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Microarray-based, high-throughput gene expression profiling of microRNAs

11 July 2018

1 reference

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HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription

11 July 2018

1 reference

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The double-stranded-RNA-binding motif: interference and much more

11 July 2018

1 reference

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Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Phosphorylation of RNA polymerase II in cardiac hypertrophy: cell enlargement signals converge on cyclin T/Cdk9.

11 July 2018

1 reference

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Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Cyclins that don't cycle--cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size.

11 July 2018

1 reference

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Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.

11 July 2018

1 reference

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Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Activation of MyoD-dependent transcription by cdk9/cyclin T2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

11 July 2018

1 reference

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The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Proteins binding to duplexed RNA: one motif, multiple functions

11 July 2018

1 reference

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Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

HIV-1 Tat interacts with cyclin T1 to direct the P-TEFb CTD kinase complex to TAR RNA.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Identification of a cyclin subunit required for the function of Drosophila P-TEFb

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Purification of P-TEFb, a transcription factor required for the transition into productive elongation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Cyclin-dependent kinase-9: an RNAPII kinase at the nexus of cardiac growth and death cascades.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

Identification of a novel isoform of Cdk9.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885667

24 September 2018

Identifiers

DOI

10.1093/NAR/GKM150

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17395637%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17395637%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference