Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells (Q24315756)

GOA release 2020-03-11

Unc-13 homolog D

1 reference

positive regulation of exocytosis

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Janice Griffith

7

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Nils Brose

12

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Jeroen Krijgsveld

8

object named as

Jeroen Krijgsveld

0 references

Peter van der Sluijs

14

object named as

Peter van der Sluijs

0 references

Nico M Wulffraat

9

object named as

Nico Wulffraat

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author name string

Maaike Neeft

1

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Marnix Wieffer

2

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Arjan S de Jong

3

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Gabriela Negroiu

4

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Corina H G Metz

5

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Alexander van Loon

6

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Henriette Koch

10

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Albert J R Heck

11

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Monique Kleijmeer

Molecular Biology of the Cell

13

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language of work or name

English

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publication date

February 2005

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published in

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volume

16

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issue

2

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page(s)

731-41

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cites work

Identification of novel MUNC13-4 mutations in familial haemophagocytic lymphohistiocytosis and functional analysis of MUNC13-4-deficient cytotoxic T lymphocytes

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rabip4′ Is an Effector of rab5 and rab4 and Regulates Transport through Early Endosomes

19 March 2017

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Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1)

19 March 2017

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Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes

19 March 2017

1 reference

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MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes

19 March 2017

1 reference

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The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking

19 March 2017

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Rab27a: A key to melanosome transport in human melanocytes

19 March 2017

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Involvement of Rab27 in antigen-induced histamine release from rat basophilic leukemia 2H3 cells

19 March 2017

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Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells

19 March 2017

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Mast Cell Degranulation RequiresN-Ethylmaleimide-Sensitive Factor-Mediated SNARE Disassembly

19 March 2017

1 reference

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Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis

19 March 2017

1 reference

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Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion

19 March 2017

1 reference

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Snares and Munc18 in synaptic vesicle fusion

19 March 2017

1 reference

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Identification of an organelle receptor for myosin-Va

19 March 2017

1 reference

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Differential control of vesicle priming and short-term plasticity by Munc13 isoforms

19 March 2017

1 reference

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Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs

19 March 2017

1 reference

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The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain

19 March 2017

1 reference

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Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming

19 March 2017

1 reference

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Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform

19 March 2017

1 reference

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Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment

19 March 2017

1 reference

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Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

19 March 2017

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19 March 2017

1 reference

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Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

The Rab5 effector EEA1 is a core component of endosome docking

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

The ins and outs of IgE-dependent mast-cell exocytosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

A general role for Rab27a in secretory cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Regulation of Membrane Transport by rab GTPases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Membrane domains in the secretory and endocytic pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Comprehensive analysis of the secreted proteins of the parasite Haemonchus contortus reveals extensive sequence variation and differential immune recognition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Regulation of transmitter release by Unc-13 and its homologues

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Deficient geranylgeranylation of Ram/Rab27 in choroideremia.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Study of the transit of an integral membrane protein from secretory granules through the plasma membrane of secreting rat basophilic leukemia cells using a specific monoclonal antibody

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Internalization and recycling to serotonin-containing granules of the 80K integral membrane protein exposed on the surface of secreting rat basophilic leukaemia cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

A complete genetic analysis of neuronal Rab3 function.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Griscelli disease: genotype-phenotype correlation in an array of clinical heterogeneity

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545907

Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 and 4 in lysosome release

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15548590