Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3 (Q24314472)

9

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Arie Geerlof

6

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Daniela Bertinetti

object named as

Daniela Bertinetti

2

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Friedrich W. Herberg

object named as

Friedrich W Herberg

10

0 references

Felix von Zweydorf

5

object named as

Felix von Zweydorf

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author name string

Kathrin Muda

1

0 references

Frank Gesellchen

3

0 references

Jennifer Sarah Hermann

4

0 references

Anette Jacob

Proceedings of the National Academy of Sciences of the United States of America

7

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language of work or name

English

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publication date

7 January 2014

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published in

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volume

111

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page(s)

E34-43

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issue

1

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cites work

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

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The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

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Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity

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LRRK2 in Parkinson's disease: protein domains and functional insights

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A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

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Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

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It takes two to tango: regulation of G proteins by dimerization

27 September 2017

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14-3-3 proteins: a number of functions for a numbered protein

27 September 2017

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14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity

27 September 2017

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27 September 2017

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How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis

27 September 2017

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Physiological substrates of cAMP-dependent protein kinase

27 September 2017

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cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons

27 September 2017

1 reference

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Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3890784

The roles of 14-3-3 proteins in signal transduction.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3890784

LRRK2 secretion in exosomes is regulated by 14-3-3.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3890784

Krebs EG: Purification and characterization of a protein inhibitor of adenosine 3',5'-monophosphate-dependent protein kinases.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3890784

Expression in Escherichia coli and characterization of the heat-stable inhibitor of the cAMP-dependent protein kinase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3890784

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1312701111

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1312701111

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1312701111

21 January 2018

Identifiers

DOI

10.1073/PNAS.1312701111

1 reference

1718581

ADS bibcode

2014PNAS..111E..34M

0 references

1718581

1 reference

1 reference

1 reference