C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity (Q24314234)

GOA release 2020-03-11

author name string

Holly B Kordasiewicz

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Randall M Thompson

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H Brent Clark

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Christopher M Gomez

Age at onset variance analysis in spinocerebellar ataxias: A study in a Dutch-French cohort

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language of work or name

English

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publication date

15 May 2006

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published in

Human Molecular Genetics

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volume

15

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issue

10

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page(s)

1587-99

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cites work

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Polyglutamine diseases: a transcription disorder?

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SCA6 mutation analysis in a large cohort of the Japanese patients with late-onset pure cerebellar ataxia

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Proteolytic cleavage and cellular toxicity of the human alpha1A calcium channel in spinocerebellar ataxia type 6.

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Polyglutamines placed into context

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Unified mechanisms of Ca2+ regulation across the Ca2+ channel family

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Nuclear targeting of proteins: how many different signals?

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PEST sequences and regulation by proteolysis

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Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human

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Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels.

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Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel

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Differential proteolysis of the full-length form of the L-type calcium channel alpha 1 subunit by calpain

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Differential expression and sequence-specific interaction of karyopherin alpha with nuclear localization sequences

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A beta 4 isoform-specific interaction site in the carboxyl-terminal region of the voltage-dependent Ca2+ channel alpha 1A subunit

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Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel

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Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function

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Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells

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Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels

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Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current

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Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

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Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor

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Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.

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Immunocytochemical localization of the alpha 1A subunit of the P/Q-type calcium channel in the rat cerebellum.

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Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission

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The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals

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Evidence for a 95 kDa short form of the alpha1A subunit associated with the omega-conotoxin MVIIC receptor of the P/Q-type Ca2+ channels

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7 January 2021

The polyglutamine expansion in spinocerebellar ataxia type 6 causes a beta subunit-specific enhanced activation of P/Q-type calcium channels in Xenopus oocytes.

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7 January 2021

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7 January 2021

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7 January 2021