Functional organization of the Sm core in the crystal structure of human U1 snRNP (Q24309502)

Small nuclear ribonucleoprotein polypeptide F

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Small nuclear ribonucleoprotein U1 subunit 70

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Small nuclear ribonucleoprotein polypeptide E

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Small nuclear ribonucleoprotein D3 polypeptide

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Small nuclear ribonucleoprotein D2 polypeptide

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Small nuclear ribonucleoprotein D1 polypeptide

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Small nuclear ribonucleoprotein polypeptide C

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Small nuclear ribonucleoprotein polypeptides B and B1

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Small nuclear ribonucleoprotein polypeptide G

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Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing

author

Reinhard Georg Lührmann

4

Reinhard Lührmann

Reinhard

Lührmann

1 reference

19 October 2023

2

Simon Trowitzsch

Simon

Trowitzsch

1 reference

19 October 2023

Markus C Wahl

5

Markus C

Wahl

1 reference

19 October 2023

Gert Weber

1

Gert

Weber

1 reference

19 October 2023

3

Berthold Kastner

Berthold

Kastner

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19 October 2023

language of work or name

English

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publication date

15 December 2010

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published in

The EMBO Journal

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volume

29

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issue

24

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page(s)

4172-84

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cites work

1 reference

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RNA binding in an Sm core domain: X-ray structure and functional analysis of an archaeal Sm protein complex

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Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure

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A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro

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Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs

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Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding

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In vivo assembly of functional U7 snRNP requires RNA backbone flexibility within the Sm-binding site

19 March 2017

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LSm proteins form heptameric rings that bind to RNA via repeating motifs

19 March 2017

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Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln

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Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particle

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Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs

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The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome

7 April 2017

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The role of RNP biogenesis in spinal muscular atrophy

27 September 2017

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Evolutionary diversification of the Sm family of RNA-associated proteins

27 September 2017

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Molecular functions of the SMN complex

27 September 2017

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Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy

27 September 2017

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Assembly of the U1 snRNP involves interactions with the backbone of the terminal stem of U1 snRNA

27 September 2017

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A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs

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Spliceosomal U snRNP core assembly: Sm proteins assemble onto an Sm site RNA nonanucleotide in a specific and thermodynamically stable manner

27 September 2017

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U2 RNA shares a structural domain with U1, U4, and U5 RNAs

27 September 2017

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27 September 2017

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Unexpected flexibility in an evolutionarily conserved protein-RNA interaction: genetic analysis of the Sm binding site

27 September 2017

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27 September 2017

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Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing.

27 September 2017

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Isolation of an active step I spliceosome and composition of its RNP core.

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An unusual chemical reactivity of Sm site adenosines strongly correlates with proper assembly of core U snRNP particles.

21 January 2018

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Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

21 January 2018

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A biochemical function for the Sm complex.

21 January 2018

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Purification of U small nuclear ribonucleoprotein particles

21 January 2018

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12 December 2020

Structural organization of ribonucleoproteins containing small nuclear RNAs from HeLa cells. Proteins interact closely with a similar structural domain of U1, U2, U4 and U5 small nuclear RNAs

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12 December 2020

The global folding of four-way helical junctions in RNA, including that in U1 snRNA

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12 December 2020

The 5' end of U2 snRNA is in close proximity to U1 and functional sites of the pre-mRNA in early spliceosomal complexes

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12 December 2020