BLM RecQ like helicase (Q885306)

P-loop containing nucleoside triphosphate hydrolase

1 reference

Winged helix-like DNA-binding domain superfamily

1 reference

Winged helix DNA-binding domain superfamily

1 reference

HRDC-like superfamily

1 reference

Helicase superfamily 1/2, ATP-binding domain, protein family

1 reference

ATP-dependent DNA helicase RecQ, zinc-binding domain, protein family

1 reference

Helicase, C-terminal domain, protein family

1 reference

DEAD/DEAH box helicase

1 reference

HRDC domain, protein family

1 reference

RQC domain, protein family

1 reference

Bloom syndrome protein, BDHCT-box associated domain, protein family

1 reference

BDHCT, protein family

1 reference

DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site, protein family

1 reference

Bloom syndrome protein, N-terminal domain, protein family

1 reference

ATP-dependent DNA/DNA annealing activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

DNA helicase activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

The Bloom's syndrome gene product is a 3'-5' DNA helicase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

IPI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

24 references

9 May 2019

Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Regulation and localization of the Bloom syndrome protein in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

hSSB1 associates with and promotes stability of the BLM helicase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Stimulation of flap endonuclease-1 by the Bloom's syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Systematic analysis of human protein complexes identifies chromosome segregation proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

four-way junction helicase activity

4 references

24 April 2018

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

DNA helicase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

four-way junction DNA binding

3 references

9 May 2019

Structure and function of the regulatory HRDC domain from human Bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

telomeric D-loop binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

telomeric G-quadruplex DNA binding

1 reference

9 May 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

8-hydroxy-2'-deoxyguanosine DNA binding

IC

1 reference

9 May 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

3 references

protein homodimerization activity

1 reference

9 May 2019

A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

four-way junction DNA binding

4 references

1 January 2018

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Structure and function of the regulatory HRDC domain from human Bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

3 references

1 January 2018

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

8 April 2019

Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

single-stranded DNA binding

3 references

1 January 2018

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Structure and function of the regulatory HRDC domain from human Bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

3 references

1 January 2018

Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

four-way junction helicase activity

5 references

9 May 2019

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

forked DNA-dependent helicase activity

3 references

1 January 2018

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

8-hydroxy-2'-deoxyguanosine DNA binding

1 reference

9 May 2019

Regulation and localization of the Bloom syndrome protein in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

intracellular anatomical structure

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

Nuclear structure in normal and Bloom syndrome cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

Nuclear structure in normal and Bloom syndrome cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

3 references

1 January 2018

Nuclear structure in normal and Bloom syndrome cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

3 references

24 April 2018

Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

The Bloom's syndrome gene product is homologous to RecQ helicases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

9 May 2019

A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

replication fork protection

1 reference

9 May 2019

Nuclear structure in normal and Bloom syndrome cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

DNA double-strand break processing

NAS

1 reference

9 May 2019

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

positive regulation of transcription, DNA-templated

1 reference

9 May 2019

The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

negative regulation of cell division

1 reference

9 May 2019

The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

cellular response to camptothecin

1 reference

9 May 2019

Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

replication fork processing

1 reference

9 May 2019

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

negative regulation of DNA recombination

1 reference

9 May 2019

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

cellular response to ionizing radiation

1 reference

9 May 2019

Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

mitotic G2 DNA damage checkpoint signaling

1 reference

9 May 2019

Regulation and localization of the Bloom syndrome protein in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

Regulation and localization of the Bloom syndrome protein in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

cellular response to hydroxyurea

1 reference

9 May 2019

Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

3 references

24 April 2018

The Bloom's syndrome gene product is homologous to RecQ helicases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

telomeric D-loop disassembly

1 reference

9 May 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

A balance between elongation and trimming regulates telomere stability in stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

3 references

24 April 2018

Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

24 April 2018

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132

protein homooligomerization

1 reference

9 May 2019

A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

regulation of DNA-dependent DNA replication

1 reference

9 May 2019

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

cellular response to DNA damage stimulus

3 references

9 May 2019

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

regulation of cyclin-dependent protein serine/threonine kinase activity

resolution of meiotic recombination intermediates

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

DNA synthesis involved in DNA repair

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

4 references

9 May 2019

The Bloom's syndrome gene product is homologous to RecQ helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

double-strand break repair via nonhomologous end joining

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

4 references

9 May 2019

The Bloom's syndrome gene product is homologous to RecQ helicases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

meiotic DNA double-strand break processing involved in reciprocal meiotic recombination

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

4 references

9 May 2019

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

negative regulation of apoptotic process

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

G-quadruplex DNA unwinding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

double-strand break repair via synthesis-dependent strand annealing

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

positive regulation of transcription, DNA-templated

negative regulation of mitotic recombination

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

alpha-beta T cell differentiation

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

positive regulation of alpha-beta T cell proliferation

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

protein complex oligomerization

3 references

1 January 2018

Oligomeric ring structure of the Bloom's syndrome helicase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

meiotic chromosome separation

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

negative regulation of thymocyte apoptotic process

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

resolution of recombination intermediates

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

regulation of DNA-dependent DNA replication

negative regulation of double-strand break repair via single-strand annealing

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

positive regulation of double-strand break repair via homologous recombination

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

regulation of signal transduction by p53 class mediator

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

DNA unwinding involved in DNA replication

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132

1 reference

Bloom syndrome protein, N-terminal domain

1 reference

Bloom syndrome protein, BDHCT-box associated domain

1 reference

HRDC domain

1 reference

DEAD/DEAH box helicase domain

1 reference

RQC domain

1 reference

ATP-dependent DNA helicase RecQ, zinc-binding domain

1 reference

Helicase superfamily 1/2, ATP-binding domain

1 reference

DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site

1 reference

Helicase, C-terminal

1 reference

Identifiers

MeSH descriptor ID

C097151

subject named as

Bloom syndrome protein

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference