Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase (Q24303548)

Protein arginine N-methyltransferase 5

GOA release 2020-03-11

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GOA release 2020-03-11

Cyclin D1

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GOA release 2020-03-11

7

Meenhard Herlyn

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author name string

Priya Aggarwal

1

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Laura Pontano Vaites

2

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Jong Kyong Kim

3

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Hestia Mellert

4

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Buddha Gurung

5

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Hiroshi Nakagawa

6

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Xianxin Hua

8

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Anil K Rustgi

9

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Steven B McMahon

10

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J Alan Diehl

The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

11

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language of work or name

English

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publication date

19 October 2010

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published in

Cancer Cell

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volume

18

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issue

4

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page(s)

329-40

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cites work

1 reference

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DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint

19 March 2017

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Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex

19 March 2017

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Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes

19 March 2017

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The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins

19 March 2017

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Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

19 March 2017

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Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1

19 March 2017

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Arginine methylation regulates the p53 response

19 March 2017

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Cycling to cancer with cyclin D1

19 March 2017

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Cyclin D1, p16 and retinoblastoma gene product expression as a predictor for prognosis in non-small cell lung cancer at stages I and II

19 March 2017

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Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

19 March 2017

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Analysis of cyclin D1 (CCND1) allelic imbalance and overexpression in sporadic human pituitary tumors

19 March 2017

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D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability

19 March 2017

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P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor

19 March 2017

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CDK-independent activation of estrogen receptor by cyclin D1

19 March 2017

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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

19 March 2017

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Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer

19 March 2017

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Purification and molecular identification of two protein methylases I from calf brain. Myelin basic protein- and histone-specific enzyme

19 March 2017

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The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression

19 March 2017

1 reference

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D-type cyclin-dependent kinase activity in mammalian cells

19 March 2017

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Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.

7 April 2017

1 reference

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PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

27 September 2017

1 reference

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Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer

27 September 2017

1 reference

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Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication

27 September 2017

1 reference

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Protein arginine methylation regulates insulin signaling in L6 skeletal muscle cells

27 September 2017

1 reference

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Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis

27 September 2017

1 reference

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Interplay between chromatin remodelers and protein arginine methyltransferases

27 September 2017

1 reference

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Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential

27 September 2017

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L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage

27 September 2017

1 reference

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Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1.

27 September 2017

1 reference

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Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma

27 September 2017

1 reference

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Inhibition of Smad antiproliferative function by CDK phosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957477

Small molecule regulators of protein arginine methyltransferases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957477

An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene

27 September 2017

1 reference

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A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957477

Regulation of the functional interaction between cyclin D1 and the estrogen receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957477

Mechanism of cyclin D1 (CCND1, PRAD1) overexpression in human cancer cells: analysis of allele-specific expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957477

Cyclin-dependent kinases regulate the antiproliferative function of Smads

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957477

Prospective study of cyclin D1 overexpression in Barrett's esophagus: association with increased risk of adenocarcinoma.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2957477

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining

29 November 2018

1 reference

12 December 2020

The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas

1 reference

12 December 2020

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

1 reference

12 December 2020

Cyclin D1/PRAD1/BCL-1 alternative transcript [B] protein product in B-lymphoid malignancies with t(11;14)(q13;q32) translocation

1 reference

12 December 2020

Cyclin D1 protein expression and function in human breast cancer

1 reference

12 December 2020

10.1016/J.CCR.2010.08.012

Identifiers

DOI

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4355472

4355472

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1 reference

1 reference